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SUMMARY:Inaugural Lectures SV - Aleksandar Antanasijevic\, Wouter Karthaus
DTSTART:20230309T171500
DTEND:20230309T190000
DTSTAMP:20260428T082544Z
UID:8acf63a15e246b074e724966d3a1831923826f5404b35ce0cf071508
CATEGORIES:Inaugural lectures - Honorary Lecture
DESCRIPTION:Prof. Aleksandar Antanasijevic\nProf. Wouter Karthaus\nDate: T
 hursday March 9\, 2023\nProgram: \n\n	17:15 - 17:25 Introduction by the De
 an and Director GHI\n	17:25 - 17:55 Prof. Aleksandar Antanasijevic\n	18:00
  - 18:10 Introduction by the Dean and Director ISREC\n	18:10 - 18:40 Prof.
  Wouter Karthaus\n	18:40 - 18:45 Closure\n	18:45 Apéritif\n\nLocation: SV
 1717\nRegistration: Click here\n\n========================================
 ====\nProf. Aleksandar Antanasijevic\n\nImmune responses visualized by ele
 ctron microscopy\n\nAbstract\nOver the past few decades we have witnessed 
 a revolution in vaccine research catalyzed by the expansion of technologie
 s for design\, manufacturing\, administration\, and evaluation of vaccines
 . Our new lab at EPFL is developing electron-microscopy-based methods for 
 rapid structural analysis of immune responses induced by vaccine candidate
 s\, pathogens and toxins. We use structural and computational biology tool
 s to study how molecular features in antigens shape antibody-mediated immu
 nity. By defining the rules for efficient antibody engagement\, we aim to 
 introduce novel engineering principles for vaccine design. In this talk\, 
 I will discuss our work on the development of EM methods and present examp
 les from the research involving viral antigens from human immunodeficiency
  virus\, enteroviruses etc.\n\nAbout the speaker\nI am a biochemist by tra
 ining\, with a strong research background in structural biology and its ap
 plication to virus and vaccine research. I completed my PhD at the Univers
 ity of Illinois at Chicago in the lab of Michael Caffrey\, where I first g
 ot exposed to methods like nuclear magnetic resonance and X-ray crystallog
 raphy. Following a postdoc in Andrew Ward's lab at the Scripps Research In
 stitute\, where I specialized in electron microscopy\, I moved to EPFL to 
 start my own research group. In our new lab\, we seek to establish a multi
 -component research program to aid structure-guided vaccine design efforts
  in different fields using electron microscopy as the primary tool.\n\n===
 =========================================\nProf. Wouter Karthaus\n\nSteroi
 d hormone regulated organs & cancers: Androgens\, lineage plasticity and b
 eyond\n\nAbstract\nProstate cancer (PCa) is one of the most common maligna
 ncies\, with more than 1.4 million new diagnoses and 375.000 deaths in 202
 0 alone. In spite of considerable heterogeneity in the mutational landscap
 e\, all primary PCa relies on the Androgen Receptor (AR) for growth and su
 rvival\, treatment of metastatic prostate cancer is aimed on disrupting AR
  function using AR signaling inhibitors (ARSI). Potent “next generation
 ” ARSI such as enzalutamide and abiraterone have been great clinical suc
 cesses\, however virtually all patients will eventually relapse\, to a dis
 ease state commonly referred to as castration resistant prostate cancer (C
 RPC). Here I will discuss the several molecular mechanisms of progression 
 to CRPC\, which include a novel phenotype switching behaviour of cancer ce
 lls called lineage plasticity.  Additionally\, I will discuss how these f
 indings on lineage plasticity can be translated to steroid hormone regulat
 ed cancers\, such as breast and endometrial cancer.\n\nAbout the speaker\n
 My research has focused on development of novel in vitro model systems to 
 study prostate biology. Which led to the development of the prostate organ
 oids methodology during my PhD.\nDuring my post-doc I used this model syst
 em to study the effects of androgen deprivation on the normal prostate as 
 well as prostate cancer. Currently the Karthaus lab still focuses further 
 developing and refining the organoid methodology\, initiation and progress
 ion of steroid hormone dependent cancers and mechanisms of resistance to d
 rug treatments.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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