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SUMMARY:BMI Seminar // Sonia Gandhi - Thinking big to see small: from macr
 oscopic to nanoscopic resolution of Parkinson’s disease
DTSTART:20230315T160000
DTEND:20230315T170000
DTSTAMP:20260428T092829Z
UID:e8c0881dd060931223c5c7ef58c83241d1bfa736fd7342189b648df0
CATEGORIES:Conferences - Seminars
DESCRIPTION:Sonia Gandhi\, Neurodegeneration Biology Laboratory\, The Fran
 cis Crick Institute\, London\, UK\nNeurodegenerative diseases are incurabl
 e progressive brain disorders that are characterised by the common feature
  of proteinopathy: the abnormal accumulation of aggregated proteins. My la
 boratory’s research program focusses on understanding how\, where and wh
 y proteins misfold in human cells and brain\, and how this affects organel
 lar homeostasis\, and function\, and ultimately leads to neuronal death. W
 e have adapted a range of single molecule and super resolution approaches 
 to study the earliest stages of protein self assembly and aggregation in h
 uman neurons and glia\, and we have described the factors that influence t
 he kinetics of the aggregation process. We have studied the functional con
 sequence of different protein aggregates in human patient derived iPSC der
 ived neurons and glia\, and reported mechanisms by which oligomeric specie
 s can induce toxicity. Funded by the global initiative\, Aligning Science 
 Across Parkinson’s\, we are now integrating single cell genomics\, singl
 e molecule imaging\, and spatial technologies to generate a detailed molec
 ular and cellular map of the human Parkinson’s brain. Our approach model
 s Parkinson’s across different scales and modalities\, integrating cellu
 lar\, computational\, and clinical neuroscience to understand causation an
 d progression in Parkinson’s.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/62550191552?pwd=OFRDVzBHb0cyVG1wYkxUSFFEMUNPdz09
STATUS:CONFIRMED
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