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SUMMARY:BMI Seminar // Li-Huei Tsai - Enhancing Gamma Oscillations in Alzh
 eimer's Disease: mechanism and pilot study in humans
DTSTART:20230623T110000
DTEND:20230623T120000
DTSTAMP:20260428T003857Z
UID:e571fd0937a1d99c69444a461ff451242673212bb245b62e2fd62582
CATEGORIES:Conferences - Seminars
DESCRIPTION:Li-Huei Tsai\, MIT\, Cambridge\, USA\nExceptionally on Friday 
 at 11 AM!\n\nRhythmic neural activity in the gamma range (30-80 Hz) is mod
 ulated during various aspects of cognitive function and is disrupted in se
 veral neurological conditions\, including Alzheimer's disease (AD). We de
 veloped an approach which we term Gamma ENtrainment Using Sensory stimuli
  (GENUS)\, using patterned light and sound stimulation at 40 Hz in AD mode
 l mice to evaluate the effects of boosting gamma oscillations. We showed
  GENUS augmented gamma power in multiple brain regions.  Moreover\, daily
  application markedly reduced amyloid and tau pathology\, attenuated degen
 eration of neurons and synapses\, and improved cognitive function in multi
 ple AD mouse models. In addition\, GENUS induced morphological and gene ex
 pression changes of various cell types\, including microglia and enhanced 
 vasodilation. GENUS also enhanced glial-mediated and lymphatic-like brain
  waste clearance\, known as glymphatic clearance\, in a VIP interneuron de
 pendent manner.  Based on these studies\, we hypothesized that gamma entr
 ainment with light and sound can be used as a disease-modifying therapeuti
 c for AD. We conducted a placebo-controlled\, randomized control trial (n 
 = 15) in subjects with probable mild AD to use our light and sound device 
 at home for one hour daily (NCT 04042922). We report interim results after
  3 months of daily 40Hz stimulation. Gamma frequency light and sound stimu
 lation can be used safely daily for 3 months and prevents AD-related degen
 eration. Induced entrainment using sensory stimulation at 40Hz shows promi
 se as a novel disease modifying therapeutic for Alzheimer’s dementia.​
 \n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/64813563657
STATUS:CONFIRMED
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