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SUMMARY:Neuro-X Seminar: Towards thalamic visual prosthetics
DTSTART:20230215T160000
DTEND:20230215T170000
DTSTAMP:20260317T095852Z
UID:aa72642330f7f490193533ff5cc02ca48b42c00f05793dabe78c1b7e
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof Gregor Rainer\nThe lateral geniculate nucleus (LGN)\, a r
 etinotopic relay center where visual inputs from the retina are processed 
 and relayed to the visual cortex\, has been proposed as a potential target
  for artificial vision.  At present\, it is unknown whether optogenetic L
 GN stimulation is sufficient to elicit behaviourally relevant percepts and
  the properties of LGN neural responses relevant for artificial vision hav
 e not been thoroughly characterized.  We demonstrate that tree shrews pre
 trained on a visual detection task can detect optogenetic LGN activation u
 sing an AAV2-CamKIIα-ChR2 construct and readily generalize from visual to
  optogenetic detection.  As temporal aspects of artificial stimulation ar
 e crucial\, we also examined tree shrew discrimination performance for vis
 ual flicker.  Neural decoding analyses in LGN and primary visual cortex (
 V1) reveal that while LGN neurons multiplex information about temporal sti
 mulation discriminations\, V1 neurons explicitly encode information about 
 one or the other discriminations but not both.  Our findings confirm the 
 LGN as a potential target for visual prosthetics and introduce a distincti
 on in stimulus encoding between thalamic and cortical representations that
  could be of fundamental importance in artificial vision.\n\n 
LOCATION:B1-06 https://plan.epfl.ch//?room==B1%206%20272.043 https://epfl.
 zoom.us/j/68653598954?pwd=REFtM21CekNIcHdIb1VHbm13bHFxUT09
STATUS:CONFIRMED
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