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SUMMARY:Understanding and reversing fibrosis
DTSTART:20230126T141500
DTEND:20230126T151500
DTSTAMP:20260510T022859Z
UID:6e88f2f66038f5fe7c59a8ef25fe362d5b84a6dcbdf3e25f45c53a32
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Uri Alon\n\nFibrosis is a pathology of excess scarring t
 hat occurs across medicine. To understand inflammation and fibrosis\, we d
 eveloped a minimal mathematical model. The model predicts two new kinds of
  fibrosis\, and a key interaction that drives the process. Inhibiting this
  interaction\, an autocrine loop in which scar-forming fibroblasts support
  their own growth\, is predicted to reverse fibrosis. Indeed\, inhibiting 
 the autocrine loop reverses fibrosis in mice models of heart attack and li
 ver cirrhosis. \n\nReferences: \n\n1. Adler\, M. et al. Principles of 
 Cell Circuits for Tissue Repair and Fibrosis. Iscience 23\, 100841 (2020
 ). \n2. Miyara\, S. et al. Circuit to target approach defines an autocr
 ine myofibroblast loop that drives cardiac fibrosis.BioRxiv\, (2023) doi:1
 0.1101/2023.01.01.522422. \n3. Wang\, S. et al. An autocrine signaling 
 circuit in hepatic stellate cells underlies advanced fibrosis in nonalcoho
 lic steatohepatitis. Sci Transl Med 15\, eadd3949 (2023). 
LOCATION:CE 1 5 https://plan.epfl.ch/?room==CE%201%205
STATUS:CONFIRMED
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