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SUMMARY:MechE Seminar: Understanding of Solid-Fluid Transitions in Embryon
 ic Tissues by Mechanics Principles
DTSTART:20230209T090000
DTEND:20230209T100000
DTSTAMP:20260414T211923Z
UID:dacef7712afca1b81f66667abff113ae2f3a3fab88eeb8889d37fad2
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Sangwoo Kim\, Department of Mechanical Engineering\, Unive
 rsity of California\, Santa Barbara\nAbstract: Tissue structure\, dynamics
 \, and physical states are tightly controlled by collective interactions a
 t cellular and subcellular scales. To theoretically understand these relat
 ions across multiple length scales and time scales\, we develop Active Foa
 m Model that incorporates essential cellular features of embryonic tissues
 \, namely the existence of extracellular spaces\, complex cell shape\, and
  non-equilibrium tension fluctuations at cell-cell contacts. Active Foam M
 odel recovers two distinct modes of solid-fluid transitions in equilibrium
 \, jamming transition and density-independent transition as limiting behav
 iors and explains a novel non-equilibrium rigidity transition governed by 
 junctional tension fluctuations. A direct measurement of stress relaxation
  as well as cell\nrearrangement in elongating zebrafish tailbud tissue sho
 ws that the observed tissue fluidization is driven by stochastic tension d
 ynamics. We further extend Active Foam Model to study the role of nuclei i
 n tissue architecture and tissue physical states and discover a nuclear ja
 mming transition governed by nuclear volume fraction and nuclear aspect ra
 tio. These results highlight the broad applicability of Active Foam Model 
 to understand embryonic development and tissue morphogenesis.\n\nBiography
 : Sangwoo Kim is a postdoctoral fellow in the Department of Mechanical Eng
 ineering at the University of California\, Santa Barbara. He completed his
  graduate degree in Theoretical and Applied Mechanics at the University of
  Illinois at Urbana-Champaign where he investigated relations between stat
 istics\, geometry\, and mechanical states in cellular matters. His current
  research focuses on theoretical understanding of biological and living sy
 stems as well as soft and active matter using mechanics and physics princi
 ples. His research interests include embryonic development\, tissue morpho
 genesis\, structure and mechanics of soft materials\, inherent structure o
 f amorphous materials\, and non-equilibrium dynamics of active matter.
LOCATION:BM 5202 https://plan.epfl.ch/?room==BM%205202 https://epfl.zoom.u
 s/j/62885854794
STATUS:CONFIRMED
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