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SUMMARY:Neuro-X Seminar: In vivo direct imaging of neuronal activity at hi
 gh temporospatial resolution
DTSTART:20230628T160000
DTEND:20230628T170000
DTSTAMP:20260916T032137Z
UID:468163ee8da68739f1b4f12184dd6637600b5f8279aa5fc1f6bc3580
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof Jang-Yeon Park\nAdvanced noninvasive neuroimaging methods
  provide valuable information on the brain function\, but they have obviou
 s pros and cons in terms of temporal and spatial resolution. Functional ma
 gnetic resonance imaging (fMRI) using blood-oxygenation-level-dependent (B
 OLD) effect provides good spatial resolution in the order of millimeters\,
  but has a poor temporal resolution in the order of seconds due to slow he
 modynamic responses to neuronal activation\, providing indirect informatio
 n on neuronal activity. In contrast\, electroencephalography (EEG) and mag
 netoencephalography (MEG) provide excellent temporal resolution in the mil
 lisecond range\, but spatial information is limited to centimeter scales. 
 Therefore\, there has been a longstanding demand for noninvasive brain ima
 ging methods capable of detecting neuronal activity at both high temporal 
 and spatial resolution. In this talk\, I will introduce a novel approach t
 hat enables Direct Imaging of Neuronal Activity (DIANA) using MRI that can
  dynamically image neuronal spiking activity in milliseconds precision\, a
 chieved by data acquisition scheme of rapid 2D line scan synchronized with
  periodically applied functional stimuli. DIANA was demonstrated through i
 n vivo mouse brain imaging on a 9.4T animal scanner during electrical whis
 ker-pad stimulation. DIANA with milliseconds temporal resolution had high 
 correlations with neuronal spike activities\, which could also be applied 
 in capturing the sequential propagation of neuronal activity along the tha
 lamocortical pathway of brain networks. In terms of the contrast mechanism
 \, DIANA was almost unaffected by hemodynamic responses\, but was subject 
 to changes in membrane potential-associated tissue relaxation times such a
 s T2 relaxation time. DIANA is expected to break new ground in brain scien
 ce by providing an in-depth understanding of the hierarchical functional o
 rganization of the brain\, including the spatiotemporal dynamics of neural
  networks.\n 
LOCATION:H8-1-D https://plan.epfl.ch//?room==H8%201%20144.167 https://epfl
 .zoom.us/j/66804967285?pwd=STNxaExCekZld2RzVGdYdXh2ZlI3dz09
STATUS:CONFIRMED
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