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PRODID:-//Memento EPFL//
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SUMMARY:ChemBio e-seminar by Prof. Kristin Koutmou (Uni Michigan) - CH-635
DTSTART:20230523T161500
DTEND:20230523T171500
DTSTAMP:20260928T200415Z
UID:a03c5945d6b6605b6954096322b87ca8a81984c9ab9e4f6c2ce5ffb0
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Kristin Koutmou\nTitle: Consequences of reshaping the RN
 A modification landscape under stress\n\nAbstract:\nCells face the dauntin
 g challenge of synthesizing the correct number of proteins at the right ti
 me with high fidelity. Messenger RNAs (mRNAs) serve as the blueprints for 
 protein synthesis by the ribosome\, and the post-transcriptional modificat
 ion of mRNA presents one avenue for cells to regulate protein production. 
 The recent discovery of mRNA chemical modifications has generated tremendo
 us excitement because these modifications have the potential to regulate m
 RNA function and control protein expression levels. Pioneering work on mRN
 A modifications have implemented sequencing-based methods to map the locat
 ion of individual chemical modifications across all of the RNA molecules i
 n a cell. Despite a rapidly growing recognition of their importance\, fund
 amental questions regarding the identity\, prevalence and functional conse
 quences of mRNA modifications remain to be answered. We are working to fil
 l these critical knowledge gaps and establish a quantitative and mechanist
 ic basis for understanding how mRNA chemical modifications impact protein 
 synthesis at the molecular level. The work presented here demonstrates the
  consequences of modifying individual uridine nucleobase positions on the 
 speed and accuracy of the ribosome\, and presents evidence suggesting a ne
 w framework for conceptualizing how key uridine modifying enzymes (pseudou
 ridine synthases) select their mRNA targets.\n\nSpeaker's biography:\nDr. 
 Kristin Koutmou is the Seyhan N. Ege Assistant Professor in the Department
  of Chemistry at the University of Michigan. She began her scientific care
 er at the University of Colorado at Denver where she obtained her B.S. in 
 Chemistry. Dr. Koutmou then moved to the Department of Chemistry at the Un
 iversity of Michigan for her doctoral work. During her time at Michigan sh
 e trained in mechanistic enzymology with Professor Carol Fierke\, studying
  how bacterial ribonuclease P binds and matures precursor tRNAs. Following
  her PhD studies\, Dr. Koutmou joined the laboratory of Professor Rachel G
 reen at the Johns Hopkins School of Medicine as a post-doctoral fellow in 
 the Department of Molecular Biology and Genetics. In the Green lab\, Dr. K
 outmou used a reconstituted in vitro translation system to investigate tra
 nslation elongation and termination. In 2016\, Dr. Koutmou returned to the
  University of Michigan to begin her independent career. Her laboratory is
  in the Department of Chemistry\, and she also holds an affiliation with t
 he Department of Biological Chemistry. Recently\, Dr. Koutmou also became 
 the Assistant Director of the graduate Program in Chemical Biology. Dr. Ko
 utmou’s lab studies the post-transcriptional control of gene regulation 
 by the ribosome. Much of the Koutmou lab’s work focuses on understanding
  the molecular level consequences of mRNA modification on protein synthesi
 s.\n\nLab website: koutmoulab.com\n 
LOCATION:https://epfl.zoom.us/j/65480995001
STATUS:CONFIRMED
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