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SUMMARY:High-resolution temporal analysis of β-cells reveals role of FoxM
 1 in protein synthesis and mitochondrial activity during metabolic stress
DTSTART:20230209T110000
DTEND:20230209T120000
DTSTAMP:20260511T073028Z
UID:ee9424deca0fc772a298b8c60611da33c4ee041f3e6b18da9c2c1bb6
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Dr. Markus Stoffel\, Group leader\, Institute for Mol
 ecular Health Sciences\,  ETH Zurich\nPancreatic β-cells display functi
 onal and transcriptional heterogeneity in health and disease. The sequence
  of events leading to β-cell heterogeneity during metabolic stress is poo
 rly understood. We have characterized β-cell responses to early metabol
 ic stress in vivo by employing RNA-seq\, ATAC-seq\, scRNA-seq\, ChIP-se
 q and real-time imaging to decipher temporal events of chromatin remodel
 ing and gene expression regulating the unfolded protein response (UPR)\, p
 rotein synthesis\, mitochondrial function and cell cycle progression. We d
 emonstrated that a subpopulation of β-cells with active UPR\, increased 
 protein synthesis and insulin secretary capacities is more susceptible to 
 proliferate after insulin depletion. Alleviation of ER stress precedes th
 e progression of cell cycle and mitosis and ensures appropriate insulin sy
 nthesis. Furthermore\, metabolic stress rapidly activates key transcript
 ion factors including FoxM1\, which impacts on proliferative and quiescent
  β-cells through previously unrecognized functions in regulating prote
 in synthesis\, ER stress and mitochondrial activity via direct repression 
 of mitochondrial encoded genes.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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