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SUMMARY:ChemBio e-seminar by Prof. Justin Kim (Harvard Med School) - CH-63
 5
DTSTART:20230509T161500
DTEND:20230509T171500
DTSTAMP:20260406T144346Z
UID:e13d58084c8e9e9bd378dc87c6845476b4dab338c402c244ab8f696a
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Justin Kim\nTitle: Bioorthogonal click and release: A ge
 neral\, rapid\, reversible bioconjugation strategy employing enamine N-oxi
 des\n\nAbstract:\nA functionally reversible bioconjugation strategy employ
 ing a new bioorthogonal dissociative reaction has been designed using enam
 ine N-oxides. The reaction is rapid\, complete\, directional\, traceless\,
  and displays broad substrate scope. Reaction rates for cleavage of small 
 molecules from proteins are fast\, and the reaction is insensitive to comm
 on aqueous buffers\, pHs between 4 and 10\, complex tissue homogenates\, a
 nd cells. Diboron reagents with bidentate and tridentate ligands also effe
 ctively reduce the enamine N-oxide to induce dissociation and compound rel
 ease. This reaction can be paired with the corresponding bioorthogonal hyd
 roamination reaction between N\,N-dialkylhydroxylamines and strained or pu
 sh-pull-activated alkynes to afford an integrated system of bioorthogonal 
 click and release via an enamine N-oxide linchpin with a minimal footprint
 . The tandem associative and dissociative reactions are useful for the tra
 celess and transient attachment of proteins and small molecules with acces
 s to a discrete\, isolable intermediate. The effectiveness of this reversi
 ble transformation is demonstrated through several applications.\n\nSpeake
 r's biography:\nJustin Kim received his AB in Chemistry and Physics and AM
  in Chemistry from Harvard College in 2007. He completed his PhD on the to
 tal synthesis of cyclotryptamine and diketopiperazine alkaloids with Prof.
  Mohammad Movassaghi at MIT in 2013 then pursued postdoctoral studies in c
 hemical biology with Prof. Carolyn Bertozzi at UC Berkeley and Stanford Un
 iversity as a Miller Institute Fellow. In 2016\, he started his faculty ap
 pointment as an assistant professor of Biological Chemistry and Molecular 
 Pharmacology at Harvard Medical School and the Department of Cancer Biolog
 y at Dana-Farber Cancer Institute. Research in his laboratory focuses on d
 eveloping biologically compatible chemistries that facilitate the study an
 d manipulation of biomacromolecules and biomaterials.\n\nLab website: http
 s://kimlab.dana-farber.org/\n 
LOCATION:https://epfl.zoom.us/j/66588193128
STATUS:CONFIRMED
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