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SUMMARY:"Steering Asymmetric Catalysis with Metal-Centered Chirality"CH-64
 0
DTSTART:20230222T171500
DTEND:20230222T181500
DTSTAMP:20260510T111833Z
UID:2ef531f62467bd983a9c21520f66846e1ab5b73447a8e0a9a2c45e62
CATEGORIES:Conferences - Seminars
DESCRIPTION:Professor Eric Meggers - Department of Chemistry\, University
  of Marburg\, Germany\nOver the past few years\, our laboratory has advanc
 ed the design and application of a novel class of powerful asymmetric cata
 lysts in which the required overall chirality originates solely from a ste
 reogenic metal center (Acc. Chem. Res. 2017\, 50\, 320\; Acc. Chem. Res. 2
 019\, 52\, 833. Such chiral-at-metal catalysts are of interest due to thei
 r intrinsic structural simplicity (only achiral ligands) and provide untap
 ped opportunities with respect to novel catalyst architectures and propert
 ies.\nOur initial design consisted of bis-cyclometalated Ir(III) (JACS 201
 4\, 136\, 2990) or Rh(III) (Chem. Sci. 2015\, 6\, 1094) complexes. More re
 cently\, we expanded the family of chiral-at-metal catalysts to Ru(II) (JA
 CS 2017\, 139\, 4322) and Fe(II) (JACS 2019\, 141\, 4569) bis-(pyridyl-NHC
 ) complexes. Most of these propeller-type complexes feature C2-symmetry wi
 th either L- (left-handed screw) or D-configuration (right-handed screw).\
 nThe presentation will provide insight into the design\, synthesis\, and a
 pplications of such chiral-at-metal catalysts including asymmetric photoca
 talysis (Nature 2014\, 515\, 100)\, electrochemistry (Nat. Catal. 2019\, 2
 \, 34)\, and enantioselective C(sp3)-H aminations (Nat. Chem. 2022\, 14\, 
 566).\n 
LOCATION:BCH 2201 https://plan.epfl.ch/?room==BCH%202201
STATUS:CANCELLED
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