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SUMMARY:"Endowing Organometallic Catalysts with a Genetic Memory: Artifici
 al Metalloenzymes"CH-640
DTSTART:20230222T171500
DTEND:20230222T181500
DTSTAMP:20260930T205116Z
UID:4d5fa356c21cb340c47198614c0792bbac20a9016427855e25c0653f
CATEGORIES:Conferences - Seminars
DESCRIPTION:Professor Dr. Thomas R. Ward\, Department of Chemistry\, Unive
 rsity of Basel\nArtificial metalloenzymes (ArMs) have attracted increasing
  attention in the past two decades as \nattractive alternatives to either
  homogeneous catalysts or enzymes. Artificial metalloenzymes \nresult fro
 m anchoring a catalytically competent abiotic metal cofactor within a host
  protein\, \nFigure. The resulting ArMs combine attractive features of bo
 th homogeneous- and bio-catalysts. \nImportantly\, they enable access to 
 new-to- nature reactions in a cellular environment.\nRelying on supramolec
 ular anchoring of an organometallic cofactor in a variety of protein \nsc
 affolds\, we have optimized the performance of ArMs for sixteen different 
 reactions.\nFollowing a general introduction to the underlying principles 
 of ArMs\, this talk will highlight our \nrecent progress in engineering a
 nd evolving such hybrid catalysts for olefin  metathesis\,  C–H  \nac
 tivation\,  hydroamination\,  and  allylic  substitution.  A\nparticu
 lar emphasis will be set on performing catalysis in a cellular environment
 .
LOCATION:BCH 2201 https://plan.epfl.ch/?room==BCH%202201
STATUS:CONFIRMED
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