BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Memento EPFL// BEGIN:VEVENT SUMMARY:U.S. CDMRP – Breast Cancer Research Program | Research Funding DTSTART;VALUE=DATE:20230328 DTSTAMP:20260510T063107Z UID:2e7a6d0fb45cfaf4b04873f16f3fe559ab942b71b48a9c6f28ad6bed CATEGORIES:Call for proposal DESCRIPTION:Aim: Through the Congressionally Directed Medical Research Pro gram (CDMRP)\, the Department of Defense is announcing the Breast Cancer R esearch Program (BCRP) Awards. Several award programs are available:\n\n T he Breakthrough Awards supports promising research that has high potential to lead to or make breakthroughs in breast cancer. The Breakthrough Award is structured with four different funding levels. Each level has a define d research scope :\n \n Funding Level 1: Innovative\, high-risk/high-rew ard research that is in the earliest stages of idea development or is an u ntested theory that addresses an important problem.\n Funding Level 2: Re search that is already supported by substantial preliminary or published d ata and strongly validates clinical translation in a well-defined context within the breast cancer landscape.\n Funding Level 3: Advanced translati onal studies with a high degree of project readiness.\n Funding Level 4: Large-scale projects that will transform and revolutionize the clinical ma nagement and/or prevention of breast cancer. Human clinical trials are req uired.\n \n \n The Clinical Research Extension Award aims to extend the da ta collection\, follow-up\, and analysis of breast cancer clinical researc h studies. Proposed research may entail a deeper molecular analysis of cli nical samples\, initiation of new correlative studies\, biomarker validati on\, or continuing clinical follow-up of patients currently/previously enr olled in an open/ongoing or completed clinical trial.\n The Era of Hope Sc holar Award supports individuals early in their careers who have demonstra ted significant potential to effect meaningful change in breast cancer. Th ese individuals should be exceptionally talented scientists who have shown that they are the “best and brightest” in their field(s)\n The Innova tor Award supports visionary individuals who have demonstrated exceptional creativity\, innovative work\, and paradigm-shifting leadership in any fi eld including\, but not limited to\, breast cancer. The Innovator Award wi ll provide these individuals with the funding and freedom to pursue their most novel\, visionary\, high-risk ideas that could accelerate progress to ending breast cancer.\n\n\nAll applications for BCRP funding must specifi cally address at least one of the Overarching Challenges as directed by Co ngress and have direct relevance to military health. The FY23 BCRP Challen ges are listed at the end of this announcement.\n\nFunding:       Bre akthrough 1 – $450K - $750K\nBreakthrough 2 – $1M - $1.5M\nBreakthroug h 3 – $4M - $5M\nBreakthrough 4 – max. $15M\nClinical Research Extensi on – $5M - $6M\nEra of Hope – max. $3M\nInnovator – max. $7M\n\nDura tion:      Breakthrough 1 – 3 years\nBreakthrough 2 – 3-4 years\nB reakthrough 3 – 4 years\nBreakthrough 4 – 4 years\nClinical Research E xtension – 4 years\nEra of Hope – 4 years\nInnovator – 4 years\n\nEl igibility: Applicants from international organizations or institutions are eligible to apply\, and there are no citizenship restrictions. All invest igators at or above the level of postdoctoral fellow (or equivalent) are e ligible for the Breakthrough Awards and Clinical Research Extension Awards . All investigators at or above the level of assistant professor (or equiv alent) are eligible for the Era of Hope Awards. All investigators at or ab ove the level of associate professor (or equivalent) are eligible for the Innovator Awards.\n\nHow to Apply: Pre-applications are submitted through the eBRAP platform. They should contain contact information\, a letter of intent\, and a list of collaborators and key personnel as suggested on the platform. Full applications will be made via a Grants.gov workspace. Appl ication packages can be downloaded from Grants.gov at any time.\n\nGrants. gov Funding Opportunity Numbers:\n\n\n Breakthrough 1-2 Award – HT9425-2 3-BCRP-BTA12 (1)\n Breakthrough 3 Award – HT9425-23-BCRP-BTA3 (2)\n Brea kthrough 4 Award – HT9425-23-BCRP-BTA4 (2)\n Clinical Research Extension Award - HT9425-23-BCRP-CREA2 (1)\n Era of Hope Scholar Award –  HT9425 -23-BCRP-EOHS (1)\n Innovator Award – HT9425-23-BCRP-INNOV (2)\n\n\nPre- Application Deadline:           (1) 5:00 p.m. Eastern time (ET)\, March 28\, 2023\n(2) 5:00 p.m. Eastern time (ET)\, March 29\, 2023\nFull Application Deadline:            program-dependent\n\n\nFurther information\n\n\n To find the full program announcements\, use the opportu nity-specific links above to connect to Grants.gov\n For questions about t he eBRAP or Grants.gov platforms\, contact the Research Office.\n\n\nFY23 BCRP Overarching Challenges: \n\n\n Prevent breast cancer (primary prevent ion)\n\n\n\n Identify determinants of breast cancer initiation\, risk\, or susceptibility\n Distinguish deadly from non-deadly breast cancers\n Conq uer the problems of overdiagnosis and overtreatment\n Identify what drives breast cancer growth\; determine how to stop it\n Identify why some breas t cancers become metastatic\n Determine why/how breast cancer cells lie do rmant for years and then re-emerge\; determine how to prevent lethal recur rence\n Revolutionize treatment regimens by replacing them with ones that are more effective\, less toxic\, and impact survival\n Eliminate the mort ality associated with metastatic breast cancer\n LOCATION: STATUS:CONFIRMED END:VEVENT END:VCALENDAR