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SUMMARY:MEchanics GAthering –MEGA- Seminar: Mechanics and biology: explo
 ring the internal dialogue of cells and tissues
DTSTART:20230316T161500
DTEND:20230316T173000
DTSTAMP:20260916T064649Z
UID:2959018f0fa17623941cb502d30d6829b9f29e16f18716e632323c75
CATEGORIES:Conferences - Seminars
DESCRIPTION:Adrien Méry (MICROBS\, EPFL)\nAbstract:\nLiving systems are n
 ever mechanically at rest : cells are constantly moving and contracting\, 
 the blood flow and respiration deform different organs and tissues\, and d
 ifferent movements are performed at the body scale. These deformations are
  perceived by the cells through mechanotransduction. They thus act as sign
 als\, involved in the regulation of numerous biological processes such as 
 morphogenesis\, homeostasis and wound healing. Thanks to the extracellular
  matrix\, an arrangement of different chemicals and fibers on which the ce
 lls rest\, these deformations can propagate over long distances. In return
 \, cells respond to these mechanical stimuli: they move\, adapt their phen
 otype or contractility\, and secrete and modify the arrangement of the ext
 racellular matrix. Mechanobiology set to task to study the interactions be
 tween biological processes and the mechanics associated to them. To this e
 nd\, biophysicists need to characterize and track the evolution of the mec
 hanical properties of the systems they study. Various tools can be utilize
 d to measure these properties depending on the scale of the model consider
 ed. At the scale of the tissue\, these measurements are required to unders
 tand how these signals are emitted\, propagated and perceived between cell
 s. We developed a method to utilize cells as actuators of their own tissue
 s thanks to optogenetics\, allowing us to estimate the elasticity and visc
 osity of the tissues. At the scale of cells\, mechanical behavior will imp
 act how cells would interact with one another\, which is critical in the i
 mmune system proper function for instance. To study the mechanics of cells
  directly\, deformability cytometry can be used to achieve a high throughp
 ut. Overall\, understanding better how mechanics govern cells and tissue b
 ehavior would allow us to apply this knowledge to synthetic morphogenesis.
  Once the rules that regulate the shape of tissues will be properly unders
 tood\, it would be possible to play with them and take control of the shap
 ing of the tissues. These advances would in turn allow progress in regener
 ative medicine and biorobotics.\n\nBiography:\nAdrien obtained his master'
 s degree in Biomedical Engineering from Grenoble INP - Phelma in 2018. He 
 completed his PhD in Physics for Life Sciences at Université Grenoble Alp
 es in 2022 where he utilized optogenetics to measure the mechanical proper
 ties of tissues. He was recruited as a post-doctoral scientist in MICROBS 
 with Prof. Sakar to study how mechanics can be used for tissue synthetic m
 orphogenesis.\n 
LOCATION:MED 2 2423 https://plan.epfl.ch/?room==MED%202%202423 https://epf
 l.zoom.us/j/62450944145?pwd=NjVSdFI4VnJEVXJiT2VnNkpJQnN2Zz09
STATUS:CONFIRMED
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