BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Memento EPFL// BEGIN:VEVENT SUMMARY:Advancing Electron Microscopy to study Parkinson’s Disease DTSTART:20230424T155500 DTEND:20230424T163500 DTSTAMP:20260507T213800Z UID:8724dd575cadd3359694f0315558adb4d9c728fa0c41f1655e235869 CATEGORIES:Inaugural lectures - Honorary Lecture DESCRIPTION:Prof. Henning Stahlberg\, Laboratory of Biological Electron Mi croscopy\, EPFL\n15:15  Inaugural lecture Prof. G. Ramirez\n15:55  Inaug ural lecture Prof. H. Stahlberg\n\nParkinson’s disease is a neurodegener ative disease characterized by Lewy body plaques in the brain\, which are filled with the protein alpha-synuclein (aSyn). Fibrils of aSyn are found in PD and other diseases\, such as Multiple System Atrophy (MSA) and Demen tia with Lewy Bodies (DLB). The structural analysis of such fibrils by cry o-electron microscopy (cryo-EM) will be presented\, and structures of diff erent aSyn fibril strains will be discussed. In parallel\, EM studies of p ost-mortem human brain will be presented.\nCryo-EM can reach atomic resolu tion for large and stable proteins but fails for smaller or flexible prote ins. To maximize high-resolution contrast\, we develop aberration-correcte d\, convergent electron diffractive ptychography imaging for single partic le cryo-EM. In another experiment\, we use stroboscopic illumination with single electrons at GHz frequency to test if this can reduce the beam dama ge for a protein samples\, thereby enabling cryo-EM data collection with h igher electron doses.\n\nBio\nProf. Dr. Henning Stahlberg is a professor a t the Institute of Physics at the EPFL and a professor ad personam at the faculty of Biology and Medicine at the University of Lausanne\, Switzerlan d. He studied physics at the TU Berlin in Germany\, received his PhD in 19 97 in structural biology (Prof. Jacques Dubochet and Prof. Horst Vogel) fr om the University of Lausanne and the EPFL in Lausanne\, Switzerland\, and his Habilitation (Prof. Andreas Engel) in 2002 from the University of Bas el\, Switzerland. He joined UC Davis in California\, USA\, in 2003 as assi stant\, then associate professor in molecular and cell biology. From 2009- 2021\, he was professor at the Biozentrum and director of the Center for C ellular Imaging and NanoAnalytics (C-CINA) of the University of Basel\, Ba sel\, Switzerland. Dr. Stahlberg was appointed as professor in 2021 at the EPFL and UNIL\, where he has established the Dubochet Center for Imaging (DCI) in Lausanne in 2020/2021\, a multi-campus research platform for cryo -electron microscopy.\nHis group\, the Laboratory of Biological Electron M icroscopy (LBEM) develops methods to advance cryo-electron microscopy\, an d the group studies the molecular mechanisms associated with the developme nt of neurodegenerative diseases.\n\nDr. Stahlberg’s scientific contribu tions include 210 publications in major peer reviewed journals and two pat ents on method development in electron microscopy. Dr. Stahlberg is recipi ent of the NSF CAREER award (2004)\, the UC Davis Chancellor’s Fellow Aw ard (2008-2013)\, the W.M. Keck Award (2009)\, and was elected honorable m ember of the Swiss NanoSciences Institute of the University of Basel (2021 ). LOCATION:CE 1 2 https://plan.epfl.ch/?room==CE%201%202 STATUS:CONFIRMED END:VEVENT END:VCALENDAR