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SUMMARY:Regulation of protein disaggregation in primates
DTSTART:20230321T141500
DTSTAMP:20260609T214958Z
UID:2af3a73947ffe0e4a496846c44e552788e46a3ef096016fdfbd8ec13
CATEGORIES:Conferences - Seminars
DESCRIPTION:Nadinath B. Nillegoda Centre for Dementia and Brain Repair at 
 the Australian Regenerative Medicine Institute Monash University\, Melbour
 ne\, Australia\nCells have evolved multitiered protein quality control sy
 stems to help maintain protein homeostasis\, but under acute or chronic pr
 oteotoxic stresses\, these systems overload and result in accumulation of 
 toxic protein aggregates. Decreased cellular capacity in aggregate clearan
 ce could trigger cell dysfunction and death leading to disease and ageing.
  Human cells possess an Hsp70-based disaggregase system to resolve a wide 
 range of protein aggregates. It is not clear how these disaggregases are a
 ssembled and regulated in mammals. We report the identification of a dedic
 ated pathway for rapidly assembling protein disaggregases during stress re
 covery after protein damage and outlines how aggregate clearance is orches
 trated in primate cells. \n\nThe zoom link is https://epfl.zoom.us/j/680
 35945854\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/68035945854
STATUS:CONFIRMED
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