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SUMMARY:Molecular Mimicry: a host subversion strategy employed by Legionel
 la pneumophila
DTSTART:20230321T121500
DTEND:20230321T131500
DTSTAMP:20260407T045617Z
UID:375492fb1f17f828bab7a588b13cc32d5f522a8f5ac012dd5d26d498
CATEGORIES:Conferences - Seminars
DESCRIPTION:Carmen Buchrieser\, Pasteur Institute\, University of Paris\nL
 egionella pneumophila\, the etiological agent of Legionnaire’s disease\,
  a severe pneumonia often fatal when not treated promptly\, is a Gram-nega
 tive bacterium present in fresh and artificial water environments where it
  replicates in aquatic\, protozoan hosts. When aerosolized bacteria are in
 haled\, they can colonize the respiratory tract\, invade alveolar macropha
 ges and replicate therein causing the disease. To replicate intracellularl
 y this bacterium secrets over 330 effectors via a type IV secretion system
  (T4SS). Certain of these effectors target the nucleus. One of these effec
 tors is a eukaryotic methyltransferase carrying a SET domain (RomA) that m
 ethylates K14 of histone H3 (H3K14me3) to counteract host immune responses
 . However\, it is not known how H3K14 methylation occurs due to L. pneumop
 hila infection as this residue is usually acetylated. We have identified a
  eukaryotic-like histone deacetylase that we named LphD in the L. pneumop
 hila genome. L. pneumophila LphD is secreted by the T4SS\, that works in s
 ynergy with RomA. The distribution of RomA and LphD within the genus Legio
 nella\, their evolution and their functional roles will be discussed.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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