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SUMMARY:Cross-anatomical single-cell definition and characterization of hu
 man adipose progenitor niche
DTSTART:20230328T170000
DTEND:20230328T180000
DTSTAMP:20260509T103358Z
UID:f6b463c3a01a49d1f06508fa34f44bb4878e977216fe68daf2ba0332
CATEGORIES:Conferences - Seminars
DESCRIPTION:Radiana Ferrero\nThis is an MD-PhD pubblic defense presentatio
 n from the Doctoral School of Biotechnology and Bioengineering.\n\n"Adip
 ose tissue plasticity is orchestrated by molecularly and functionally dive
 rse cells within the stromal vascular fraction (SVF). While several mouse 
 and human adipose SVF cellular subpopulations have now been identified\, w
 e still lack an understanding of the cellular and functional variability o
 f adipose stem and progenitor cell (ASPC) populations across human fat dep
 ots. To address this\, we performed single-cell and bulk RNA-seq analyses 
 of >30 Lin–SVF samples across four human adipose depots\, revealing two 
 ubiquitous hASPC subpopulations with distinct proliferative and adipogenic
  properties but also depot- and BMI-dependent proportions. Furthermore\, w
 e identified an omental-specific\, high IGFBP2-expressing stromal populat
 ion that transitions between mesothelial and mesenchymal cell states and i
 nhibits hASPC adipogenesis through IGFBP2 secretion. Our analyses highligh
 t the molecular and cellular uniqueness of different adipose niches while 
 our discovery of an anti-adipogenic IGFBP2+ omental-specific population pr
 ovides a new rationale for the biomedically relevant\, limited adipogenic 
 capacity of omental hASPCs."\n\nContact directly the organizer for further
  information.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/69137253509
STATUS:CONFIRMED
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