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VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:EPFL BioE Talks SERIES  "High-Throughput Mechanical Phenotyping fo
 r In-Vitro Diagnostics"
DTSTART:20230320T160000
DTEND:20230320T170000
DTSTAMP:20260408T025900Z
UID:56a5c245db315a242896d83bba9726b137174fcc038e9538ff4e0e3f
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Jochen Guck\, Max Planck Institute for the Science of Li
 ght\, Erlangen (DE)\nWEEKLY EPFL BIOE TALKS SERIES\n\nAbstract:\nThe mecha
 nical properties of cells have long been heralded as a useful inherent and
  sensitive marker of disease. Despite many proof-of-concept demonstrations
  to this effect\, a major roadblock to general application has been a pauc
 ity of appropriate tools for the convenient quantification of such propert
 ies. This has changed with the recent advent of high-throughput microfluid
 ic techniques. As one such technique\, we have introduced real-time deform
 ability cytometry (RT-DC) which permits the continuous physical single-cel
 l characterization of large populations (> 100.000 cells) with analysis ra
 tes of 1\,000 cells/s — approaching that of conventional fluorescence-ba
 sed flow cytometers. Using RT-DC we can sensitively detect physiological a
 nd pathological changes in cell function by image-based parameters such as
  size\, shape\, deformability\, and any other information contained in an 
 image. For example\, we have recently demonstrated its utility for detecti
 ng blood mechanical changes in the context of Covid-19\, which could be ca
 usally involved in the progression of the disease. Combined with quick mec
 hanical dissociation\, also tissue biopsies are now accessible for RT-DC t
 o diagnose solid tumors. In general\, mechanical phenotyping adds a new fu
 nctional\, marker-free and unbiased dimension to flow cytometry with diver
 se applications in biology\, biotechnology and medicine.\n\nBio:\nJochen G
 uck received his PhD in Physics from the University of Texas at Austin in 
 2001. After being a group leader at the University of Leipzig\, he moved t
 o the Cavendish Laboratory at Cambridge University as a Lecturer in 2007 a
 nd was promoted to Reader in 2009. In 2012 he became Professor of Cellular
  Machines at the Biotechnology Center of the Technische Universität Dresd
 en. As of October 2018 he is Director at the Max Planck Institute for the 
 Science of Light and the Max-Planck-Zentrum für Physik und Medizin in Erl
 angen\, Germany\, and since August 2020 Professor of Biological Optomechan
 ics in the Physics Department of the Universität Erlangen-Nürnberg. His 
 research centers on exploring the physical properties of biological cells 
 and tissues\, and their importance for cell function and behavior. He also
  develops novel photonic\, microfluidic and scanning-force probe technique
 s for the study of these optical and mechanical properties. The ultimate g
 oal is utilizing this insight for novel diagnostic and therapeutic approac
 hes. Guck has authored over 200 peer-reviewed publications and 8 patents. 
 His work has been recognized by several awards\, amongst them the Cozzarel
 li Award by the National Academy of Sciences (USA) in 2008\, the Paterson 
 Medal and Prize by the Institute of Physics (UK) in 2011\, an Alexander-vo
 n-Humboldt Professorship in 2012\, and the Wilhelm Ostwald Medal by the Sa
 xonian Academy of Sciences in 2022.\n\n\nZoom link (with one-time registra
 tion for the whole series) for attending remotely: https://go.epfl.ch/EPFL
 BioETalks\n\n\nInstructions for 1st-year Ph.D. students who are under EDBB
 ’s mandatory seminar attendance rule:\nIF you are not attending in-perso
 n in the room\, please make sure to\n\n	send D. Reinhard a note before noo
 n on seminar day\, informing that you plan to attend the talk online\, and
 \n	be signed in on Zoom with a recognizable user name (not a pseudonym mak
 ing it difficult or impossible to be identified).\n\nStudents attending th
 e seminar in-person should collect a confirmation signature after the talk
  - please print your own signature sheet beforehand (71 kB pdf available f
 or download here).\n\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://go.epfl.ch/
 EPFLBioETalks
STATUS:CONFIRMED
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