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SUMMARY:Solid Tumors: From Engineered Macrophages for Anti-tumor Immunity 
 to Genome Instability
DTSTART:20230410T090000
DTEND:20230410T100000
DTSTAMP:20260508T053828Z
UID:3262c302f5c480d385cca817e54f74307355dd81a9c417251bfd4a83
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Dennis E. Discher\, University of Pennsyvania\, Philadel
 phia\, PA (USA)\nBIOENGINEERING SEMINAR\n \nAbstract:\nMacrophages are ab
 undant in solid tumors and typically associate with poor prognosis\, but m
 acrophage clusters in tumor nests have also been reported as beneficial ev
 en though dispersed macrophages would have more contacts with cancer cells
 . Here\, by maximally engineering phagocytic activity and maximizing macro
 phage numbers\, we discover cooperative phagocytosis by cell clusters in r
 apidly growing immuno-tumoroids and solid tumors in vivo. The results fit 
 the calculus of proliferation-versus-engulfment\, and rheological measurem
 ents and molecular perturbations provide a basis for understanding phagocy
 tic disruption of a tumor’s cohesive forces in soft cellular phases. We 
 will finish with ongoing work on chromosome instability that predominates 
 in solid tumors and implications for immune interactions.\n\nBio:\nDennis 
 E. Discher\, Ph.D.\, is Robert D. Bent Professor and Director of the NCI-P
 hysical Sciences Oncology Center/Project.\nDischer began at Penn in 1996 a
 fter a PhD at UC Berkeley & UC San Francisco and following an NSF Fellowsh
 ip in computational biophysics in British Columbia. His lab focused first 
 on membrane biophysics and polymer mimetics for solid tumor therapies\, an
 d then discovered matrix elasticity effects on stem cell differentiation a
 nd nucleus mechanosensing. Recent efforts focus on mechanobiology of DNA d
 amage and genome variation\, as well as ‘self’ pathways in macrophage 
 attack of solid tumors. He is an elected member of the US National Academy
  of Medicine\, the US National Academy of Engineering\, the American Assoc
 iation for the Advancement of Science\, and on the Editorial Board of Scie
 nce.\n\n\nZoom link for attending remotely: https://epfl.zoom.us/j/6636278
 6747\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/66362786747
STATUS:CONFIRMED
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