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SUMMARY:BMI Special Seminar // Xiaoke Chen - Circuitry and molecular mecha
 nisms underlying descending pain facilitation
DTSTART:20230630T110000
DTEND:20230630T120000
DTSTAMP:20260924T065925Z
UID:1fc35f206673bb635bdc874e4bc15ae3ac939fa3e2806e388db1318a
CATEGORIES:Conferences - Seminars
DESCRIPTION:Xiaoke Chen\, Stanford University\, California\, USA\nSpinal c
 ord-projecting neurons in the rostral ventromedial medulla (RVMSC neurons
 ) play active roles in pain facilitation. However\, the underlying circuit
 ry and molecular mechanisms remain largely unknown. We show that acute act
 ivation of OPRM1+ RVMSC neurons does not facilitate pain in normal mice\
 , but activity of these neurons is required for both initiation and mainte
 nance of chronic mechanical hypersensitivity in mouse models of inflammato
 ry and neuropathic pain. Excitatory collicular inputs are essential for up
 regulating pseudokinase CaMKv in the OPRM1+ RVMSC neurons after nerve in
 jury and causing mechanical hypersensitivity. Up- or down- regulation of C
 aMKv is sufficient to drive or reverse mechanical hypersensitivity. Togeth
 er\, our results reveal a collicular-medulla-spinal cord pathway that driv
 es persistent pain and substantiate CaMKv as a key molecular determinant o
 f chronic mechanical hypersensitivity.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/64813563657
STATUS:CONFIRMED
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