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SUMMARY:Alzheimer’s Drug Discovery Foundation – Accelerating Drug Disc
 overy for Frontotemporal Degeneration| Research Funding
DTSTART;VALUE=DATE:20230519
DTSTAMP:20260506T170539Z
UID:62fade230a9e29b0f6445db7f2225e13cbcbddb826be489f93cf7f19
CATEGORIES:Call for proposal
DESCRIPTION:Aim:  There are currently no FDA approved disease-modifying t
 reatments available for frontotemporal dementia (FTD)\, and symptomatic tr
 eatments only provide limited benefit for patients. Recent scientific adva
 nces have provided an increased understanding of pathogenic mechanisms und
 erlying FTD and are driving the development of potential disease-modifying
  therapies. The Alzheimer’s Drug Discovery Foundation (ADDF) and The Ass
 ociation for Frontotemporal Degeneration (AFTD) seek to accelerate this pr
 ogress by supporting innovative small molecule and biologic (antibodies\, 
 oligonucleotides\, peptides\, gene therapy etc.) drug development programs
  for FTD through this request for proposals (RFP).\n\nThe funding prioriti
 es for this RFP are:\n\n	Lead optimization of novel disease-modifying comp
 ounds\, including medicinal chemistry refinement and in vitro ADME.\n	In v
 ivo testing of novel lead compounds\, biologics\, vaccines\, or repurposed
  drug candidates in relevant animal models for pharmacokinetics\, dose-ran
 ge finding\, target engagement\, in vivo efficacy\, and/or preliminary rod
 ent tolerability studies.\n\n\nFunding:       $150\,000 - $200\,000\n
 \nDuration:      1 year\, with potential for follow-up funding\n\nElig
 ibility: Funding is open to researchers and clinicians worldwide at academ
 ic medical centers and universities or nonprofits. Industry partnerships a
 re encouraged.\n\nHow to Apply: Applications are reviewed in a two-step pr
 ocess: Letters of Intent (LOI) are the first step\, and are submitted thro
 ugh the ADFF Funding Portal. ADDF’s science team will evaluate LOIs to d
 etermine whether the proposed project is consistent with the ADDF's missio
 n and funding priorities. LOI decisions will be sent within three weeks of
  submission. Step 2 is an invited full proposal\, which should include a d
 etailed project narrative\, budget and justification\, and biographical in
 formation.  When formulating the budget\, note that the following costs a
 re not covered: Indirect costs/Overhead\, Publication costs\, Equipment\, 
 and Travel. See the full Application Instructions for more details.\n\nDea
 dlines:    19 May 2023 (letter of intent)\n              
            28 July 2023 (full proposal\, by invitation)\n\nFurthe
 r information\n\n\n	More information about the program is available here\n
 	Detailed application instructions are here\n	The application portal can b
 e found here\n	For any other questions\, please contact the Research Offic
 e\n
LOCATION:
STATUS:CONFIRMED
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