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SUMMARY:On the relevance of structural annotations for disulfide bridge pr
 ediction - Julien Becker
DTSTART:20121102T111500
DTEND:20121102T121500
DTSTAMP:20260609T201338Z
UID:188e085bc0f9389eb8daa7e79f7866cd8d677c9ae3b1840f577618a6
CATEGORIES:Conferences - Seminars
DESCRIPTION:Julien Becker of Bioinformatics and Modeling (c/o L. Wehenkel)
 \nDisulfide bridges strongly constrain the native structure of many protei
 ns and predicting their formation is therefore a key sub-problem of protei
 n structure and function inference. A large body of approaches for this 
 prediction problem rely on different kinds of classifiers and slightly dif
 fer in their experimental protocol. Therefore\, the comparison of the conc
 lusions of these works is difficult.\n\nIn this talk\, I will propose an e
 xtensive study which aims at establishing the relevance of various structu
 ral-related annotations in the context of a disulfide pattern predictor. I
 n order to achieve this goal\, I will introduce a tractable and interpreta
 ble feature selection methodology\, based on forward selection of feature 
 functions. We will show that only a very limited number of annotations are
  sufficient to construct a high performance disulfide pattern predictor.
LOCATION:AI-1-153 http://plan.epfl.ch/?lang=fr&room=AI1153
STATUS:CONFIRMED
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