BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:EPFL BioE Talks SERIES  "Approaching Functional Glycomics"
DTSTART:20230424T160000
DTEND:20230424T170000
DTSTAMP:20260511T081200Z
UID:a4512408caf31d1864750e543a4d42728149cedf117ae2797d684338
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Katrine Ter-Borch Gram Schjoldager\, Dept. of Cellular a
 nd Molecular Medicine\, University of Copenhagen (DK)\nWEEKLY EPFL BIOE TA
 LKS SERIES\n\nAbstract:\nLiving cells from all domains of life are covered
  with sugar-based structures and glycans are involved in numerous biologic
 al processes. Glycosylation is an abundant and important post-translationa
 l modification\, where complex glycans are added to proteins thereby drama
 tically increasing the structural diversity\, changing the physiochemical 
 properties of the final proteins and ultimately creating novel proteoforms
 \, but our insight into the specific function and regulation of glycans on
  individual proteins is vastly unexplored. The tremendous structural diver
 sity of glycans attached to proteins poses analytical challenges that limi
 t the research of specific functions of protein glycosylation. Now major a
 dvances in proteomics and gene editing are opening global ways to explore 
 protein glycosylation through analysing and targeting enzymes involved in 
 glycosylation processes. Here I will outline some of our efforts combining
  gene engineering and sensitive glycoproteomics for dissection and discove
 ry of glycosylation sites and biological functions of protein glycosylatio
 n.\n\nAbout the speaker:\nI am a co-PI at the Copenhagen Center for Glycom
 ics where my major focus is to explore the biological role of protein glyc
 osylation in health and disease. In the mammalian cell\, protein glycosyla
 tion is orchestrated by more than 200 enzyme glycosyltransferases\, decora
 ting proteins with different sugar chains expanding the size of the proteo
 me. We explore the function of these glycosyltransferases and their glycan
  products by precise gene editing strategies where we knockout individual 
 transferases in cells and animal models and use the resulting models to ex
 plore and dissect the biology of protein glycosylation.\n\n\n\nZoom link (
 with one-time registration for the whole series) for attending remotely: h
 ttps://go.epfl.ch/EPFLBioETalks\n\n\nInstructions for 1st-year Ph.D. stude
 nts who are under EDBB’s mandatory seminar attendance rule:\nIF you are 
 not attending in-person in the room\, please make sure to\n\n	send D. Rein
 hard a note before noon on seminar day\, informing that you plan to attend
  the talk online\, and\n	be signed in on Zoom with a recognizable user nam
 e (not a pseudonym making it difficult or impossible to be identified).\n\
 nStudents attending the seminar in-person should collect a confirmation si
 gnature after the talk - please print your own signature sheet beforehand 
 (71 kB pdf available for download here).\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://go.epfl.ch/
 EPFLBioETalks
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR