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SUMMARY:Wellcome Leap Program: Dynamic Resilience
DTSTART;VALUE=DATE:20230525
DTSTAMP:20260406T222140Z
UID:61c745013193bfda759eb1190508f7f900d58fd711a1cdd74acae434
CATEGORIES:Call for proposal
DESCRIPTION:\nFunding for projects seeking to address key fundamental ques
 tions to drive the measurement\, modelling and testing capabilities needed
  to advance new methods of promoting healthy\, whole lives into older age.
 \n\nFull program announcement\n\nAmount : \n\n	Award amounts will be dep
 endent on specific proposals and work selected for funding.\n	There are no
  pre-set number of awards.\n	US$60\,000\,000 funds will be awarded.\n\n\nI
 mportant Dates: \n\n\n	Submission Deadline: 25 May 2023 \n\n	\n		7-page ab
 stracts submitted (from individual organizations or teams) that address on
 e or more program areas.\n	\n	\n	Abstract Feedback:  09 June 2023\n	\n		A
 ll submissions will receive technical and/or programmatic feedback as well
  as a recommendation to submit or not submit a full proposal.\n	\n	\n	Prop
 osal decision : 09 August 2023\n	\n		All submissions will receive a ‘sel
 ected for funding’ or ‘not selected for funding’ decision. Those sel
 ected will proceed to contract signature as the final gate with work expec
 ted to commence within approximately 30 days.\n	\n	\n\nDuration :  minim
 um of 3 years (with a potential additional one-year option)\nEligiblity :
 \n \n\n	Performers from universities and research institutions: small\, m
 edium and large companies (including venture-backed)\; and government or n
 on-profit research organizations are invited to propose.\n	Wellcome Leap a
 ccepts project proposals from any legal entity\, based in any legal jurisd
 iction\, including academic\, non-profit\, for-profit\, and regulatory/pro
 fessional organizations.\n	Note: Multiple collaborators can be on a single
  submission\, but only the Principal Investigator will be able to submit t
 he application on the portal.\n\n\nThrust Areas: \n \n\n	Discover and int
 egrate markers of human dynamic resilience that identify individuals prior
  to a stress event (SE) with prediction accuracy of >85% sensitivity and >
 90% specificity for clinical outcomes post-SE (e.g.\, return to health\, f
 railty progression\, loss of independence\, death). \n	Develop multi-scal
 e models that link the biomarkers predictive of loss of steady state and d
 ynamic resilience to mechanism. It will be necessary to show that identifi
 ed mechanisms (some of which may overlap with known hallmarks of ageing) e
 ither promote and maintain homeostasis\, or are causative of resilience lo
 ss. Such models and demonstration of mechanism can be at the cellular\, ti
 ssue\, system\, or whole-body scale.\n	Validate the clinical and developme
 ntal utility of measures\, models\, and candidate preventative interventio
 ns to promote resilience in at-risk populations by undertaking specific\, 
 targeted trials. Of particular interest are trials involving preventative 
 interventions in older adults prior to predictable stress events such as e
 lective laparoscopic or orthopaedic surgery\, or cancer therapy and that f
 ocus both on demonstrating pre-stressor predictive clinical outcome accura
 cy of >85% sensitivity and >90% specificity with respect to frailty progre
 ssion and interventions that seek at least a 25% reduction in the number o
 f patients showing frailty progression following the stress event.\n\n\nHo
 w to Apply :\n \n\n	Download guidelines\n	Download abstract template (an
 d cost and schedule template)\n	We (Wellcome Leap) will remind you when th
 e application portal opens on 18 May.\n	Upload your abstract and submit yo
 ur application before 25 May at 11:59pm ET.\n	More details will be provide
 d for the proposal round of submissions.\n\n\nFor further information:\n 
 \n\n	FAQ’s:  If you have questions\, please review the FAQ Section (thi
 s was updated 25 April 2023.\n	Send inquires to DR@wellcomeleap.org\n	The 
 Research Office for EPFL related questions\n\n\n\n\n 
LOCATION:
STATUS:CONFIRMED
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