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SUMMARY:DLN: Attending to the ups and downs of Lewy body dementia: An expl
 oration of cognitive fluctuations
DTSTART:20230627T121500
DTEND:20230627T131500
DTSTAMP:20260919T052643Z
UID:607131bc9994dd2295bac62f8431cd871ab739d75160484a732d4e01
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof John-Paul Taylor\nDementia with Lewy bodies (DLB) and Par
 kinson's disease dementia (PDD) share similarities in pathology and clinic
 al presentation and come under the umbrella term of Lewy body dementias (L
 BD). Fluctuating cognition is a key symptom in LBD and manifests as altere
 d levels of alertness and attention\, with a marked difference between bes
 t and worst performance. Cognition and alertness can change over seconds o
 r minutes to hours and days of obtundation. Cognitive fluctuations can hav
 e significant impacts on the quality of life of people with LBD as well as
  potentially contribute to the exacerbation of other transient symptoms in
 cluding\, for example\, hallucinations and psychosis as well as making it 
 difficult to measure cognitive effect size benefits in clinical trials of 
 LBD.\n\nHowever\, this significant symptom in LBD is poorly understood. In
  my presentation I will discuss the phenomenology of cognitive fluctuation
 s\, how we can measure it clinically and limitations of these approaches. 
 I will then outline the work of our group and others which has been focuss
 ed on unpicking the aetiological basis of cognitive fluctuations in LBD us
 ing a variety of imaging approaches (e.g. SPECT\, sMRI\, fMRI and EEG). I 
 will then briefly explore future research directions.\n 
LOCATION:H8-1-D https://plan.epfl.ch//?room==H8%201%20144.167 https://epfl
 .zoom.us/j/67634696620?pwd=RldxMVp2eHhKcjBxV21nZFc2Wnl5dz09
STATUS:CANCELLED
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