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SUMMARY:Halogen–Bonding Catalysis for Organic Synthesis
DTSTART:20230704T161500
DTEND:20230704T173000
DTSTAMP:20260508T082111Z
UID:b1902fb154d7c47658fa8132755ba4974f17ea12db63d3ec02d05796
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Govindasamy Sekar\, Indian Institute of Technology\, Mad
 ras\, India\nHalogen–Bonding Catalysis for Organic Synthesis \n\nProf. S
 ekar Govindasamy\nDepartment of Chemistry\, IIT Madras\, INDIA\ngsekar@iit
 m.ac.in \n\nIn recent years\, halogen bond donor organocatalysts have been
  employed to activate the Lewis basic functional groups.1 The halogen–bo
 nding (XB) interaction between the Lewis bases and the halogen(I) reagents
  or halonium ions intermediates are shown to enhance the reactivity and se
 lectivity of organic reactions.1b Recently\, our research group has develo
 ped new iodine(I) and iodine(IIII) halogen bond donor catalysts for organi
 c reactions (Figure 1).2\,3 For example\, NBS and in situ–generated acet
 yl hypoiodite (CH3COOI) have been employed for selective oxidation of hete
 ro benzylic C(sp3)–H bond to C(sp2)–O and C(sp3)–O bonds via activat
 ion of the heterocyclic ring. The halogen–bonded iodonium ions have been
  utilized as stable and key oxidants to develop domino oxidation of benzyl
 ic secondary alcohols to synthesize α–hydroxy ketones. Also\, several o
 rganic reactions have been developed using XB catalysts along with visible
  light.\n\n\n\n\n\nReferences\n[1]  (a) G. Cavallo\, P. Metrangolo\, R. M
 ilani\, T.  Pilati\, A. Priimagi\, G.  Resnati\, G. Terraneo\, Chem. Rev
 . 2016\, 116\, 2478. (b) S. Guha\, I. Kazi\, A. Nandy\, G. Sekar\, Eur. J.
  Org. Chem. 2017\, 23\, 5497. (c) R. L. Sutar\, S. M. Huber\, ACS Catal. 2
 019\, 9\, 9622.\n[2]  (a) I. Kazi\, S. Guha\, G. Sekar\, Org. Lett. 2017\
 , 19\, 1244. (b) S. Guha\, I. Kazi\, P. Mukherjee\, G. Sekar\, Chem. Commu
 n.\, 2017\, 53\, 10942. (c) S. Guha\, G. Sekar\, Chem. Eur. J. 2018\, 24\,
  14171.\n[4]  (a) S. Guha\, I. Kazi\, G. Sathish\, G. Sekar\, J. Org. Che
 m. 2022\, 87\, 5424. (b). G. Sekar\, N. Anuradha\, Indian Patent No. 408
 736 (30/12/2021) and 406714 (02.12.2021).
LOCATION:BCH 2201 https://plan.epfl.ch/?room==BCH%202201
STATUS:CONFIRMED
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