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SUMMARY:Real-time immune recognition
DTSTART:20230509T150000
DTEND:20230509T160000
DTSTAMP:20260407T162126Z
UID:7e3923dce499b6b9db961bb646a6c8f87db0ba9f107478f9c4dc237a
CATEGORIES:Conferences - Seminars
DESCRIPTION:Michael Laessig - University of Cologne\nB-cells recognise a n
 ew antigen when it binds to a cognate\, high-affinity receptor. In an acut
 e primary infection\, following initial recognition by high-affinity cells
 \, a rapidly increasing antigen population could spread recognition to man
 y low-affinity lineages. How do immune systems achieve specificity of reco
 gnition in real time? Here we show that B-cells can efficiently recognise 
 antigens by a kinetic proofreading mechanism that is tuned to the complexi
 ty of the immune repertoire. The resulting proliferation-recognition dynam
 ics of a primary infection can me mapped onto a generalised Luria-Delbrüc
 k process\, akin to the dynamics of the classic fluctuation experiment. Ou
 r model predicts specific power law statistics of activated B-cells\, whic
 h are in accordance with empirical data and explain clinical characteristi
 cs of acute infections\, including the emergence of elite neutralisers and
  the effects of immune ageing. Thus\, data from acute infections emerge as
  a new probe into the global architecture and functional principles of imm
 une repertoires.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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