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SUMMARY:Recapitulating Complex Human Tissues using Organ-on-chip and Organ
 oid Technologies
DTSTART:20230530T110000
DTEND:20230530T120000
DTSTAMP:20260408T052754Z
UID:3f4687814cd96c04e7a2aa16263611dd4f4c5aeecffd73657615569b
CATEGORIES:Conferences - Seminars
DESCRIPTION:Peter Loskill\, NMI\, Natural and Medical Sciences Institute\,
  University of Tübingen\, Germany\nDrug discovery and development to dat
 e has relied on animal models\, which are useful\, but fail to resemble hu
 man physiology. One promising solution is the combination of microfluidics
 \, biomaterials\, and organoid technology to recapitulate 3D tissue struct
 ure and function in physiological environments. Such Organ-on-Chip models 
 combine human genetic background\, in vivo-like tissue structure\, physiol
 ogical functionality\, and “vasculature-like” perfusion. We have devel
 oped a variety of OoCs that incorporate complex human 3D tissues and keep 
 them viable and functional over multiple weeks\, including “Tumor-on-chi
 p”\, “Retina-on-chip”\, “Choroid-on-chip”\, “Heart-on-chip”\
 , “Pancreas-on-chip and “Adipose-on-chip” systems.  These complex h
 uman-relevant models put the research community now in a position to provi
 de answers to questions that animal models were not and to explore new par
 adigms in drug development\, personalized medicine\, toxicity screening\, 
 and mechanistic research.\nPeter Loskill1\,2\,3\n1 NMI Natural and Medical
  Sciences Institute at the University of Tübingen\,\nReutlingen\, German
 y\n2 Institute of Biomedical Engineering\, Faculty of Medicine\, Eberhard 
 Karls University Tübingen\, Österbergstr.3\, 72074 Tübingen\, Germany\n
 3 3R-Center for In vitro Models and Alternatives to Animal Testing\, Eberh
 ard Karls University Tübingen\, Österbergstr.3\, 72074 Tübingen\, Germa
 ny\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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