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SUMMARY:Cellular and Pathogenic Protein Indicators of Disease in Huntingto
 n’s Disease and X-Linked Dystonia Parkinsonism Human Brain Tissue
DTSTART:20230606T100000
DTEND:20230606T110000
DTSTAMP:20260919T215415Z
UID:e3901305b0f44dbc0032b87ec2e80386188bc364e88dc144dbe8bed8
CATEGORIES:Conferences - Seminars
DESCRIPTION:Malvindar Singh-Bains\, Ph.D. and Adelie Tan\, Ph.D.\, Univers
 ity of Auckland Centre for Brain Research\, Auckland (NZ)\nBIOENGINEERING 
 SEMINAR\n \nAbstract:\nHuntington’s disease (HD) and X-linked Dystonia 
 Parkinsonism (XDP) are both hereditary\, progressive neurogenerative brain
  conditions featuring heterogenous movement\, psychiatric and cognitive di
 sturbances with variable symptomatology between patients. Dr. Singh-Bains
 ’s PhD and early post-doctoral research focused on elucidating the cellu
 lar basis of symptom heterogeneity in HD through conducting design-based s
 tereological studies in clinically characterized post-mortem human brain t
 issue housed within the Neurological Foundation Human Brain Bank in the Ce
 ntre for Brain Research\, University of Auckland. Her expertise in human b
 rain tissue processing and dissection resulted in her involvement in the d
 evelopment of the first human brain bank in the Philippines as part of an 
 international collaborative effort to characterize XDP\, a newly discovere
 d condition endemic to the Filipino Island of Panay. Dr. Tan recently comp
 leted her PhD under the supervision of Dr. Singh-Bains focusing on the cha
 racterization of neurovascular cellular involvement in HD cortical tissue 
 through the development of high-throughout automated analysis approaches a
 pplied to human brain tissue microarrays\, combined with in vitro characte
 rization of living primary human brain cells (pericytes) derived from HD p
 ost-mortem tissue. This presentation will focus on current projects (1) el
 ucidating the involvement of pathogenic proteins in HD and (2) elucidating
  the neuropathology of XDP\, through a combination of high-throughout and 
 detailed analysis approaches in post-mortem human brain tissue.\n\n\nZoom 
 link for attending remotely: https://epfl.zoom.us/j/67113149944
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153 https://epfl.zoom.u
 s/j/67113149944
STATUS:CONFIRMED
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