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VERSION:2.0
PRODID:-//Memento EPFL//
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SUMMARY:EPFL BioE Talks SERIES  "Bacterial Proprioception: Precise Adaptat
 ion to Mechanical Stimulus in the Chemotaxis Output"
DTSTART:20230515T160000
DTEND:20230515T170000
DTSTAMP:20260408T060320Z
UID:5aaca6f893a9adcfe02a8f5e2aa88c1c427216eaa99ff0bc8a59a312
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Pushkar P. Lele\, Artie McFerrin Department of Chemical 
 Engineering\, Texas A&M University\, College Station\, TX (USA)\nWEEKLY EP
 FL BIOE TALKS SERIES\n\nAbstract:\nBacteria sense and adapt to mechanical 
 cues in their environment\, which appears crucial in their quest to coloni
 ze surfaces. Cell appendages that can function as tactile sensors are part
 icularly important in mechanosensing and surface adaptation. The bacterial
  flagellum is a well-known example of such a mechanosensor. The flagellum 
 is rotated by a transmembrane rotary motor that engages one or two force g
 enerators (stator units) when it is newly assembled. The stator units util
 ize the proton-motive force to deliver mechanical forces\, turning the fla
 gellum in Escherichia coli. We discovered that when the flagellum adheres
  to a solid surface\, the motor responds to the increased viscous resistan
 ce to rotation by recruiting additional stator units. A catch bond within 
 the stator structure likely underpins the mechanosensitive recruitment of 
 the units. The stator has since been implicated in downstream signaling ev
 ents linked to numerous physiological changes\, including biofilm formatio
 n. A major question is how stator recruitment in the membrane initiates in
 tracellular signaling. Our recent work demonstrated that stator recruitmen
 t modulates the binding of CheY-P\, the chemotaxis response regulator\, to
  the cytoplasmic interface of the flagellar motor. Notably\, this change i
 n binding affinity is driven purely by mechanical force delivered by the s
 tator units to the membranous motor components. Experiments further reveal
 ed significant parallels between the flagellar responses to mechanical and
  chemical stimuli in the chemotaxis network. The newly discovered link bet
 ween mechanosensing and chemotaxis function is essential in surface adapta
 tion. It may also provide a handle for understanding epigenetic mechanisms
  of adaptation to antibiotic stress in bacteria.\n\nBio:\n\n	Postdoctoral 
 Fellow\, Molecular and Cellular Biology\, Harvard University\, Cambridge M
 A\, 2015\n	Ph.D.\, Chemical Engineering\, University of Delaware\, Newark\
 , 2010\n	Bachelor\, Chemical Engineering\, UDCT\, Mumbai\, 2005\n\n\n\n\nZ
 oom link (with one-time registration for the whole series) for attending r
 emotely: https://go.epfl.ch/EPFLBioETalks\n\n\nInstructions for 1st-year P
 h.D. students who are under EDBB’s mandatory seminar attendance rule:\nI
 F you are not attending in-person in the room\, please make sure to\n\n\n	
 send D. Reinhard a note before noon on seminar day\, informing that you pl
 an to attend the talk online\, and\n	be signed in on Zoom with a recogniza
 ble user name (not a pseudonym making it difficult or impossible to be ide
 ntified).\n\nStudents attending the seminar in-person should collect a con
 firmation signature after the talk - please print your own signature sheet
  beforehand (71 kB pdf available for download here).\n 
LOCATION:BM 5202 https://plan.epfl.ch/?room==BM%205202 https://go.epfl.ch/
 EPFLBioETalks
STATUS:CONFIRMED
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