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PRODID:-//Memento EPFL//
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SUMMARY:ChemBio seminar by Prof. Chayasith Uttamapinant (VISTEC) - CH-635
DTSTART:20230530T161500
DTEND:20230530T171500
DTSTAMP:20260510T202429Z
UID:c4dca2932c97595b87919fbbab5c9db32c144413984c58d9cdaa5e5b
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Chayasith Uttamapinant\nTitle: Engineering sustainable r
 esources for CRISPR-based diagnosis of infectious diseases\n\nAbstract:\nI
  will discuss our development of CRISPR-based diagnostics for infectious d
 iseases toward point-of-care (POC) use outside of labs. We have developed 
 a robust multiplexed CRISPR-based detection using orthogonal CRISPR-associ
 ated nucleases to simultaneously diagnose SARS-CoV-2 infection and pinpoin
 t the causative SARS-CoV-2 variant of concern (VOC)—including recent glo
 bally dominant VOCs Delta (B.1.617.2) and Omicron (B.1.1.529) and have imp
 lemented the CRISPR-based test technology for COVID-19 diagnosis\, with th
 e approval of the FDA of Thailand. The platform has features for POC use: 
 premixed freeze-dried reagents for easy use and storage\; convenient smart
 phone-based readouts\; and a one-pot variant of the multiplexed detection.
  Beyond COVID-19\, our team and collaborators are applying CRISPR-based di
 agnostics to neglected fatal tropical diseases\, whose diagnosis is challe
 nging yet critically important for timely treatment. To reduce reliance on
  proprietary reagents and enable sustainable use of the technology in low-
  and middle-income countries\, we locally produce a complex recombinase po
 lymerase isothermal amplification (RPA) reaction typically used in conjunc
 tion with CRISPR-based detection and demonstrate its equivalent efficiency
  to commercial counterparts. The ability to produce RPA in house enables u
 s to probe the phase separation-dependent amplification of RPA and enginee
 r its bottleneck components\, further improving the reaction for multiplex
 ed diagnosis.\n\nSpeaker's biography:\nTao Uttamapinant received his AB in
  Chemistry from Harvard College in 2007. He completed his PhD in biologica
 l chemistry with Prof. Alice Ting at MIT in 2013\, then trained with Prof.
  Jason Chin as a Marie Curie International Incoming and Career Development
  Fellow at Medical Research Council Laboratory of Molecular Biology from 2
 013-2018. Tao started his faculty appointment at VISTEC\, Thailand in late
  2018. Research in his laboratory focuses on the development of new tools 
 to characterize locally synthesized proteins and proteoforms\; plastic bio
 remediation\; and open-source molecular diagnostic tools.\n\nLab website: 
 https://www.vistec.ac.th/academic/faculty_detail.php?school=BSE&id=83\nUpd
 ated publications: https://scholar.google.co.uk/citations?user=uUliPp0AAAA
 J&hl=en\n 
LOCATION:CE 1 2 https://plan.epfl.ch/?room==CE%201%202
STATUS:CONFIRMED
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