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SUMMARY:Harnessing the early-life gut microbiome to prevent atopic disease
DTSTART:20230629T090000
DTEND:20230629T100000
DTSTAMP:20260430T195938Z
UID:9a1900cee5472d685afe8fe70d0213e166ab34ca32183493f44131a1
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Olaf PERDIJK Department of Immunology and Pathology\, Muco
 sal Immunology Research Group\, Central Clinical School\, Monash Universit
 y\, Melbourne\, VIC 3004\, Australia\nThe last decade of microbiome resear
 ch has shed light on the crucial role for the gut microbiome in maintainin
 g systemic immune and metabolic homeostasis. Particularly during early lif
 e\, nutrition and gut microbes play a significant role in shaping immune d
 evelopment and tolerance induction to harmless food antigens and allergens
 . Environmental factors that disrupt or delay this natural succession (e.g
 . due to early-life antibiotics use) can dysregulate immune homeostasis\, 
 predisposing neonates to atopic disease and childhood asthma. We are just 
 starting to appreciate the complex interplay between the gut microbiota\, 
 diet\, and immune homeostasis at distal organs such as the lung. My recent
  findings reveal a novel pathway through which antibiotics use in early li
 fe can predispose the lung to allergic airway inflammation and highlight t
 he therapeutic potential of microbial metabolites. This is an area with a 
 plethora of challenges but huge opportunities to harness microbes\, metabo
 lites and the gut-lung axis could be key to the development of effective p
 reventative and therapeutic strategies against respiratory diseases.\n 
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153 https://epfl.zoom.u
 s/j/67658987036
STATUS:CONFIRMED
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