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SUMMARY:Gene Regulation and Phenotypic Memory in Fluctuating Environments
DTSTART:20230711T121500
DTEND:20230711T131500
DTSTAMP:20261005T043919Z
UID:11debbe45b6e5f5df977bb5262765cdccc761fe8509e623c3d9bd77e
CATEGORIES:Conferences - Seminars
DESCRIPTION:Edo Kussell\, Departments of Biology and Physics\, New York Un
 iversity\nBacterial survival in fluctuating environments relies on gene re
 gulatory mechanisms that activate and repress specific genes in response t
 o environmental cues. By measuring growth of bacteria in a fluctuating env
 ironment using microfluidic devices\, we have found that phenotypic memory
  coupled with gene regulation in the sugar operons of Escherichia coli i
 ncreases long-term growth rates. In this talk\, I will describe the molecu
 lar basis of phenotypic memory in the lac operon\, and present results o
 n the competitive advantage of different levels of memory in a periodicall
 y changing environment. In the context of metabolic fluctuations\, I will 
 discuss the question of how selection maintains a gene regulatory mechanis
 m and acts on gene expression levels to enhance phenotypic memory.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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