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SUMMARY:No blood\, no guts\, no glory: the Drosophila gut-immune axis duri
 ng injury
DTSTART:20230727T100000
DTEND:20230727T110000
DTSTAMP:20260930T215131Z
UID:a628a6dfdcefd445ae5c0a031d12f0bcd1dd663d9cfb5b72b4c9d0f9
CATEGORIES:Conferences - Seminars
DESCRIPTION:Sveta Chakrabarti\n\nDepartment of Developmental Biology and G
 enetics\, Indian Institute of Science\, Bengaluru\, India\nTissue damage i
 s a significant threat to organisms\, resulting from infections or injurie
 s. Animals have evolved mechanisms to recognize damage-associated molecula
 r patterns (DAMPs) and activate pathways for repair and inflammation. Howe
 ver\, the molecular mechanisms and cellular responses to DAMPs remain poor
 ly understood. In this study\, blood cell gene expression profiles were an
 alyzed at injury sites in flies. The upregulation of JAK/STAT cytokine upd
 -3 (IL-6) and the Toll pathway\, typically associated with pathogen infect
 ion\, was observed. Intracellular accumulation of hydrogen peroxide and it
 s import into blood cells via the water channel Prip were found to be cruc
 ial for upd-3 induction post-injury. Impairment of cytokine upd-3 producti
 on was observed in blood cells lacking Prip. Interestingly\, injury-based 
 activation of blood cells enhanced protection against Enterococcus faecali
 s infection\, dependent on hydrogen peroxide production at the injury site
 .\n\nThe gut houses a large portion of immune cells in humans and plays a 
 vital role in nutrient absorption. Previous research demonstrated that blo
 od cells in flies act as messengers between injury sites and the intestine
  to regulate stem cell proliferation. Failure of blood cell activation and
  hydrogen peroxide signaling post-injury led to inhibited intestinal stem 
 cell proliferation and increased susceptibility to injury. My research aim
 s to uncover the molecular mechanisms underlying intestinal stem cell prol
 iferation triggered by thoracic injury in Drosophila
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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