BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Memento EPFL// BEGIN:VEVENT SUMMARY:Chemical approaches to decoding histone epigenetics DTSTART:20230926T161500 DTEND:20230926T173000 DTSTAMP:20260414T211912Z UID:0da9fc6a99f941b524652ca57989fdeb8c4c05b970449728b51a2bb7 CATEGORIES:Conferences - Seminars DESCRIPTION:Prof. David Li\, University of Honkg Kong\nHistone posttransla tional modifications (PTMs)\, such as phosphorylation\, methylation and ac etylation\, play crucial roles in regulating many fundamental cellular pro cesses\, such as gene transcription\, DNA replication\, DNA damage repair\ , chromosome segregation and cell differentiation. Increasing evidences ha ve indicated that PTMs of histones can serve as a heritable ‘code’ (so -called ‘histone code’)\, which provides epigenetic information that a mother cell can pass to its daughters. Histone code is ‘written’ or ‘erased’ by enzymes that generate or remove the modifications of histo nes. Meanwhile\, ‘readers’ of histone code recognize specific histone modifications and ‘translate’ the code by executing distinct cellular programs necessary to establish the diverse cell phenotypes.\n\nWhile a la rge number of PTMs have been identified on histones\, the biological signi ficance of vast majority of them remains poorly understood. This is partic ularly the case for those newly discovered histone modifications such as l ysine crotonylation\, succinylation\, fatty-acid acylation\, and the modif ications present at histone cores such as methylation at H3 lysine 79. Stu dies of these new PTMs are hindered by the lack of knowledge about their r egulating enzymes (i.e.\, ‘writers’ and ‘erasers’) and functional binding proteins (i.e.\, ‘readers’). To fill this knowledge gap\, here I present the development of novel chemical tools and approaches\, in com bination with the state-of-the-art biochemistry\, proteomics and cell biol ogy methods\, to comprehensively identify ‘writers’\, ‘erasers’ an d ‘readers’ of histone PTMs and examine their regulatory mechanisms an d cellular functions.\n  LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 STATUS:CONFIRMED END:VEVENT END:VCALENDAR