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SUMMARY:Molecular basis of heterochromatin formation and regulation
DTSTART:20230915T161500
DTEND:20230915T180000
DTSTAMP:20260428T074228Z
UID:af305a2275cf645006737c62a6ec13287b07ef30fb860b802bd22e63
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Galia Debelouchina (University of California\, San Diego
 )\nHeterochromatin protein 1α (HP1α) plays a central role in the organiz
 ation of nuclear content and in the regulation of gene expression and chro
 matin compaction. HP1α binds to chromatin regions enriched in histone H3 
 K9 trimethylation and coordinates a complex network of events that leads t
 o the formation of dense heterochromatin neighborhoods and gene silencing.
  It is believed that this process involves the phase separation of HP1α p
 roteins into liquid droplets and gel-like compartments. Capturing the mole
 cular interactions that drive heterochromatin formation has been difficult
  due to the heterogeneous nature of chromatin and HP1α\, both of which co
 ntain rigid and dynamic components. To understand this system\, we have us
 ed a biophysical toolbox that includes solution and solid-state NMR spectr
 oscopy\, fluorescence imaging\, and coarse-grained molecular dynamics simu
 lations. These approaches have allowed us to 1) capture the molecular inte
 ractions that drive the phase separation of HP1α\, 2) describe how HP1α 
 interacts with chromatin to bring about gene silencing\, and 3) understand
  how these processes can be regulated by chromatin and HP1α binding partn
 ers. Our strategy can also be applied to other protein systems that underg
 o phase separation to provide atomic resolution details of this elusive bi
 ological process.\n\n 
LOCATION:CH G1 495 https://plan.epfl.ch/?room==CH%20G1%20495
STATUS:CONFIRMED
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