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VERSION:2.0
PRODID:-//Memento EPFL//
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SUMMARY:Neuro-X Seminar: Closed-Loop Deep Brain Stimulation for Mental Dis
 orders: Progress Towards Rationally Designed\, Circuit-Oriented Treatment
DTSTART:20231010T120000
DTEND:20231010T130000
DTSTAMP:20260407T021135Z
UID:3157de09e087e53ed688b9e23ab57f4661d5e582e2da320e957d2667
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof Alik Widge\nMental disorders arise from brain circuit dys
 functions\, but most of our treatments target the whole brain rather than 
 defined circuits. Deep brain stimulation (DBS) is a more circuit-directed 
 approach that has done well in movement disorders\, but has very mixed res
 ults in randomized clinical trials for mental illness. Part of the difficu
 lty is that psychiatric DBS is delivered in a trial-and-error fashion\, wi
 thout clear evidence that it engages the target circuits. I will present r
 esults along two lines: developing better biomarkers to guide that target 
 engagement\, and designing new stimulation protocols that reliably produce
  circuit-level physiologic change. In biomarkers\, we have identified ways
  in which DBS can augment top-down executive function\, have linked those 
 changes to cortical electrophysiology\, and demonstrated human symptom rel
 ief from closed-loop stimulation. In animals\, we have demonstrated new st
 imulation techniques that change specific aspects of circuit connectivity.
  Taken together\, these offer the prospect of a new generation of rational
 ly designed brain stimulation therapies. 
LOCATION:H4-02-A https://plan.epfl.ch/?room==H4%202%20232.080 https://epfl
 .zoom.us/j/68619087706?pwd=ZUdrMkRTL3c5RDE0NjZqdi8wOWFaQT09
STATUS:CONFIRMED
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