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SUMMARY:ChemBio Seminar by Prof. Michael Nash (Uni Basel/ETH Zurich): "Com
 prehensive Mutational Profiling of Cancer Therapeutic Enzymes by Proximity
 -Based Sequencing
DTSTART:20230919T161500
DTEND:20230919T171500
DTSTAMP:20260510T213530Z
UID:4bd415d175e949492f32291ee88d064f2fd88c213ba3589124797407
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof Michael Nash\nTitle: Comprehensive Mutational Profiling o
 f Cancer Therapeutic Enzymes by Proximity-Based Sequencing CH-636\n\nAbstr
 act:\nUnderstanding the complex relationships between enzyme sequence\, fo
 lding stability and catalytic activity is crucial for applications in indu
 stry and biomedicine. However\, current enzyme assay technologies are limi
 ted by an inability to simultaneously resolve both stability and activity 
 of enzymes\, and to couple these to gene sequences at large scale. In this
  talk\, I will summarize my lab’s recent work developing a technique cal
 led  Enzyme Proximity-Seq (EP-Seq)\, a deep mutational scanning method th
 at leverages peroxidase-mediated radical labeling to to quantify the influ
 ence of thousands of mutations on stability and catalytic activity in a si
 ngle experiment.\n\nSpeaker's biography:\nProf. Michael Nash earned his BS
  in Cybernetics from UCLA in 2006\, where he focused on the Formation of L
 ipid Bilayer Membranes in Microfluidic Devices for Nanopore Sensing. He th
 en completed a dual PhD in Bioengineering and Nanotechnology under the gui
 dance of Profs. Patrick Stayton and Paul Yager at the University of Washin
 gton - Seattle in 2010. His research during this period concentrated on na
 noparticle systems for biomarker identification. Pursuing postdoctoral wor
 k\, Nash relocated to Ludwig-Maximilian University in Munich\, and by 2013
 \, he had transitioned to the role of an independent group leader. In 2016
 \, he became Assistant Professor with a joint appointment at both the Univ
 ersity of Basel and ETH Zurich\, where he was promoted to Associate Profes
 sor in 2021. Nash and his team use a multi-scale approach to design artifi
 cial molecular systems\, spanning from single molecules to macroscopic mat
 erials\, aiming to create engineered protein systems for medical therapies
 .\n\n\nLab website:\nhttp://nash.chemie.unibas.ch/\n\n\n 
LOCATION:CE 1 4 https://plan.epfl.ch/?room==CE%201%204
STATUS:CONFIRMED
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