BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:EPFL BioE Talks SERIES  "A Novel Neuroimmune Human Brain Organoid 
 Model to Study Microglia in Health and Disease"
DTSTART:20231030T160000
DTEND:20231030T170000
DTSTAMP:20260428T022456Z
UID:10a4d4f9e674ae09791e573a6ddf346fd6dac2935c881753d2ea6076
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Abed A. Mansour\, Department of Medical Neurobiology\,
  The Institute for Medical Research (IMRIC)\, Faculty of Medicine\, The 
 Hebrew University of Jerusalem (IL)\nWEEKLY EPFL BIOE TALKS SERIES\n\nAbst
 ract:\nMicroglia are specialized brain-resident macrophages that play cruc
 ial roles in brain development\, homeostasis\, and disease. However\, unti
 l now\, the ability to model interactions between the human brain environm
 ent and microglia has been severely limited. To overcome these limitations
 \, we developed an in vivo xenotransplantation approach that allows us to 
 study functionally mature human microglia (hMGs) that operate within a phy
 siologically relevant\, vascularized immunocompetent human brain organoid 
 (iHBO) model. Our data show that organoid-resident hMGs gain human-specifi
 c transcriptomic signatures that closely resemble their in vivo counterpar
 ts. In vivo two-photon imaging reveals that hMGs actively engage in survei
 lling the human brain environment\, react to local injuries\, and respond 
 to systemic inflammatory cues. Finally\, we demonstrate that the transplan
 ted iHBOs developed here offer the unprecedented opportunity to study func
 tional human microglia phenotypes in health and disease and provide experi
 mental evidence for a brain-environment-induced immune response in a patie
 nt-specific model of autism with macrocephaly.\n\nBio:\nEducation:\n2005 -
  2011\nPh.D. in Neuro-Developmental Genetics\nSupervisor: Prof. Nissim Ben
 -Arie\nDept. of Cell and Developmental Biology\, Hebrew university of Jeru
 salem (IL)\n\n2000 - 2003\nMSc\, Medical Science\nHebrew University-Hadass
 ah Medical School (IL)\n\n1997 - 2000\nBSc\, Biology\nThe Hebrew Universit
 y of Jerusalem (IL)\n\n\nExperience:\nJan 2021 - Present\nAssistant Profes
 sor\nDept. Medical Neurobiology\, Institute for Medical Research\nFaculty 
 of Medicine-Hebrew University of Jerusalem (IL)\n\nFeb 2015 - Present\nPos
 tdoctoral Research Associate\nFred H. Gage Lab\, Salk Institute for Biolog
 ical Studies\, La Jolla\, CA (USA)\n\nDec 2011 - Jan 2015\nPostdoctoral Re
 search Fellow\nDr. Jacob (Yaqub) Hanna Lab\, Laboratory for Pluripotent Ce
 ll Studies\nDept. of Molecular Genetics\, Weizmann Institute of Science (I
 L)\n\n\nZoom link (with one-time registration for the whole series) for at
 tending remotely: https://go.epfl.ch/EPFLBioETalks\n\n\nInstructions for 1
 st-year Ph.D. students who are under EDBB’s mandatory seminar attendance
  rule:\nIF you are not attending in-person in the room\, please make sure 
 to\n\n	send D. Reinhard a note before noon on seminar day\, informing that
  you plan to attend the talk online\, and\n	be signed in on Zoom with a re
 cognizable user name (not a pseudonym making it difficult or impossible to
  be identified).\n\nStudents attending the seminar in-person should collec
 t a confirmation signature after the talk - please print your own signatur
 e sheet beforehand (71 kB pdf available for download here).\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://go.epfl.ch/
 EPFLBioETalks
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR