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SUMMARY:Building Tissues: From Cellular to Granular
DTSTART:20230913T140000
DTEND:20230913T150000
DTSTAMP:20260508T032405Z
UID:03d91d9b142bbe5cb1776d51b3bc50e7d44edffbe675781e0024263b
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Brendan Harley\, University of Illinois at Urbana-Champa
 ign\, IL (USA)\nBIOENGINEERING SEMINAR\n \nAbstract:\nAdvances in the fie
 lds of tissue engineering and regenerative medicine require biomaterials t
 hat instruct\, rather than simply permit\, a desired cellular response. A 
 major challenge to progress in our field is the complex organization of th
 e tissues in our bodies\, which are hierarchical\, vary in space and time\
 , and can differ person-to person. Prof. Harley’s research program is de
 veloping approaches to structurally and biomolecularly pattern biomaterial
 s to enable tissue regeneration after injury as well as to study processes
  linked to homeostasis and disease progression outside of the body. A majo
 r area of our work targets development of a degradable biomaterial to rege
 nerate craniomaxillofacial bones and musculoskeletal insertions. We are us
 ing bioinspired design motifs to create composite materials that instruct 
 desired cell activities while retaining mechanical competence required for
  clinical translation. I will describe (granular) hydrogel models to study
  niche regulation of hematopoietic stem cells and patient-derived glioblas
 toma specimens. These tools enable study of dynamic processes such as nich
 e remodeling and reciprocal signaling linked to stem cell quiescence as we
 ll as the role of angiocrine signals and immune interactions on invasive s
 preading and drug resistance in primary brain cancer. We are adapting thes
 e approaches to develop hierarchical models of the endometrial tissue micr
 oenvironment to investigate trophoblast invasion and endometrial pathologi
 es.\n\nBio:\nBrendan Harley is the Robert W. Schaefer Professor in the Dep
 t. of Chemical and Biomolecular Engineering at the University of Illinois 
 at Urbana-Champaign. He received a B.S. in Engineering Sciences from Harva
 rd University (2000)\, a Sc.D. in Mechanical Engineering from MIT (2006)\,
  and performed postdoctoral studies at the Joint Program for Transfusion M
 edicine at Children’s Hospital Boston (2006 – 2008). His research grou
 p develops biomaterial platforms to dynamically regulate cell behavior for
  applications in musculoskeletal regeneration\, hematopoietic stem cell bi
 omanufacturing\, as well as to investigate endometrial pathologies and inv
 asive brain cancer. He has received funding from the NSF\, NIH\, American 
 Cancer Society\, the U.S. Army\, and the AO Foundation. Prof. Harley co-fo
 unded a regenerative medicine company\, Orthomimetics Ltd.\, to commercial
 ize a biomaterial for osteochondral regeneration.\nDr. Harley has received
  a number of awards and honors including an NSF CAREER award (2013)\, the 
 Young Investigator Award (2014) and the Clemson Award for Basic Research (
 2021) from the Society for Biomaterials (2014)\, as well as university res
 earch\, teaching\, and promotion awards (U. Illinois). He is an elected Fe
 llow of the American Association for the Advancement of Science (2014)\, t
 he American Institute for Medical and Biological Engineering (2018)\, and 
 the Biomedical Engineering Society (2021).\n\n\nZoom link for attending re
 motely: https://epfl.zoom.us/j/64538523844\n\n\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/64538523844
STATUS:CANCELLED
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