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SUMMARY:Electrostatic Mechanisms in T Cell Triggering
DTSTART:20231003T140000
DTEND:20231003T150000
DTSTAMP:20260406T210245Z
UID:aa60c0a9787cc01a2890c4612a9037ade694c080341d1a71771284db
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Chenqi Xu\, Shanghai Institute of Biochemistry and Cell 
 Biology\, Chinese Academy of Sciences\, Shanghai (China)\nBIOENGINEERING S
 EMINAR\n \nAbstract:\nElectrostatic interaction is one of the fundamental
  forces mediating biomolecular interactions. In immunoreceptor signaling\,
  a spatiotemporal electrostatic network formed by immunoreceptors\, acidic
  phospholipids\, ions and other signaling molecules regulate conformation\
 , phosphorylation\, clustering\, and degradation. Using the T cell recepto
 r (TCR) as a system\, we show the importance of electrostatic interactions
  in regulating safety\, sensitivity and specificity of antigen responses. 
 Introducing the TCR electrostatic motif into Chimeric Antigen Receptor (CA
 R) improves long-term persistence and antigen sensitivity of CAR-T cells\,
  leading to improved antitumor immunity.\n\nBio:\nChenqi Xu is now a princ
 ipal investigator at Shanghai Institute of Biochemistry and Cell Biology (
 SIBCB)\, Distinguished Adjunct Professor of the Chinese Academy of Science
 s\, and also serves as a deputy director of the State Key Laboratory of Mo
 lecular Biology. Chenqi completed his PhD training in protein chemistry wi
 th Dr. Chengwu Chi in 2004 at SIBCB. A part of his PhD work was done in Un
 iversity of Leuven and University of Hasselt in Belgium\, under supervisio
 n of Drs. Jan Tytgat and Emmy Van Kerkhove. He then received postdoctoral 
 training in immunology with Dr. Kai Wucherpfennig at Dana Farber Cancer In
 stitute\, Harvard Medical School. In 2009\, he moved back to SIBCB to star
 t his independent program focusing on T cell signaling and metabolism. The
  Xu lab has developed cutting-edge biochemical and biophysical tools to st
 udy immunoreceptor signaling and translates the basic knowledge to the dev
 elopment of engineered T cell therapy. In addition\, he is interested in t
 he fundamental functions of membrane lipids in T cell biology and have dem
 onstrated the application potential of cholesterol-based immunotherapy. Hi
 s works have been published in Nature\, Cell and other prestigious journal
 s\, and selected as Top 10 Science Breakthroughs in China. He has received
  many awards\, including the 2022 Chinese Biological Investigators Society
  Young Investigator Award and the 2023 Xplorer prize.\n\n\n\n\nZoom link f
 or attending remotely: https://epfl.zoom.us/j/67431130421\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/67431130421
STATUS:CONFIRMED
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