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SUMMARY:BMI Distinguished Seminar // Evan Macosko: Spatial and Single Cell
  Genomics for Next Generation Neuroscience
DTSTART:20231012T140000
DTEND:20231012T150000
DTSTAMP:20260508T110725Z
UID:afd29b0d86638858491144f86675bcf8f88c78f2fd4b87b843e7c615
CATEGORIES:Conferences - Seminars
DESCRIPTION:Evan Macosko\, Broad Institute\, Cambridge\, USA\n\nThe advent
  of next generation sequencing ushered in a ten-year period of exuberant t
 echnology development\, enabling the quantification of gene expression and
  epigenetic features within individual cells\, and within intact tissue se
 ctions.  In this seminar\, I will outline our technological contributions
 \, beginning with the development of Drop-seq\, a method for high-throughp
 ut single cell analysis\, followed by the development of Slide-seq\, a tec
 hnique for measuring genome-wide expression at 10 micron spatial resolutio
 n.  Using a combination of these techniques\, we recently constructed a c
 omprehensive cell type atlas of the adult mouse brain\, positioning cell t
 ypes within individual brain structures.  I will discuss the major findin
 gs from this dataset\, including emerging principles of neurotransmission\
 , and the localization of disease gene signatures to specific cell types.
   Finally\, I will introduce a new spatial technology\, Slide-tags\, that
  unifies single cell and spatial genomics into a single\, highly scalable 
 assay.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/64813563657
STATUS:CONFIRMED
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