BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:The role of epigenetics in neurons
DTSTART:20230929T150000
DTEND:20230929T160000
DTSTAMP:20260427T221232Z
UID:58e1a5a709e47649165aff71bcc98c1d86c566d2f7236e52f6f25e89
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Yusuke Kishi  IQB\, University of Tokyo \nWhat makes me is 
 my memory. Since ancient times\, the memory substance of individuals has b
 een one of our greatest mysteries. What we do know now\, at least\, is tha
 t our memories are encoded in the neurons of our brain. Given that the epi
 genome consists of cellular memory\, the epigenome of neurons should encod
 e the memory of individuals. However\, the mechanisms of memory formation 
 based on epigenetic regulation in neurons are still unclear. Our laborator
 y aims to elucidate the memory substance of individuals encoded in the epi
 genome of neurons.\n     We are now mainly focusing on the role of the
  epigenome in the memory of aging. It has been well known in many tissues 
 that epigenome\, mainly DNA methylation\, contains information on aging an
 d age-associated decline of the tissues. However\, the epigenetic changes 
 in neurons\, not the whole brain\, have not been elucidated. Here\, we com
 prehensively analyzed ten epigenome modifications on young and aged hippoc
 ampal neurons. Our data suggest that dysregulation of H3K27me3\, a repress
 ive histone modification catalyzed by Polycomb group proteins\, during neu
 ronal aging is associated with susceptibility to the age-associated declin
 e of brain functions\, such as the development of neurodegenerative diseas
 es\, excess brain inflammation\, geriatric epilepsy\, and cognitive declin
 e.\n     We are also interested in the other context related to the ch
 anges in brain function. We recently started to analyze the neuronal epige
 nome of mice that have experienced social-isolation stress or brain injury
  on their motor cortex. Through analyzing neuronal epigenome in the mice t
 hat undergo unique experiences or psychiatric diseases\, our laboratory tr
 ies to reveal the neuronal epigenome encoding memory and to manipulate bra
 in function via epigenome editing.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/69573460120
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR