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SUMMARY:Vibrational Photothermal (VIP) Microscopy: A New Window to Watch L
 ife
DTSTART:20231016T160000
DTEND:20231016T170000
DTSTAMP:20260510T042344Z
UID:35df769c96ac4a128ca541c4fbe513ad93fd8b17b58d87fbd6368027
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Ji-Xin Cheng\, Boston University\, Boston\, MA (USA)\nBI
 OENGINEERING SEMINAR\n \nAbstract:\nDye-free chemical-bond imaging opens 
 a window for life science and materials science by providing chemical info
 rmation with minimal perturbation to molecules. Infrared and Raman microsc
 opies are widely used\, yet limited by poor spatial resolution or very slo
 w imaging speed. Recently developed coherent anti-Stokes Raman scattering 
 and stimulated Raman scattering microscopy enabled high-speed chemical ima
 ging\, whereas their performance is limited by a non-resonant background o
 r a cross phase modulation. Vibrational excitation and subsequent relaxati
 on efficiently generates heat\, making photothermal detection a natural an
 d sensitive means of imaging chemical bonds. AFM-IR has allowed nanoscale 
 infrared imaging\, but not applicable to live cells. This presentation wil
 l introduce a novel optically detected chemical microscopy called vibratio
 nal photothermal (VIP) microscopy. Modalities include mid-infrared phototh
 ermal (MIP) microscopy and simulated Raman photothermal (SRP) microscopy. 
 Principle\, instrumentation\, and ground-breaking applications to life sci
 ence will be discussed.\n\nBio:\nJi-Xin Cheng\, Moustakas Chair Professor
  in Photonics and Optoelectronics\, Professor of Biomedical Engineering\, 
 of Electrical & Computer Engineering\, of Chemistry and of Physics\, atten
 ded University of Science and Technology of China (USTC) from 1989 to 1994
 . From 1994 to 1998\, he carried out his PhD study on bond-selective chemi
 stry at USTC. As a graduate student\, he worked as a research assistant at
  Universite Paris-sud (France) on vibrational spectroscopy and the Hong Ko
 ng University of Science and Technology (HKUST) on quantum dynamics theory
 . After postdoctoral training on ultrafast spectroscopy at HKUST\, he join
 ed Sunney Xie’s group at Harvard University as a postdoc\, where he spea
 rheaded the development of CARS microscopy that allows high-speed vibratio
 nal imaging. Cheng joined Purdue University in 2003 as Assistant Professor
  in Weldon School of Biomedical Engineering and Department of Chemistry\, 
 promoted to Associate Professor in 2009 and Full Professor in 2013. He joi
 ned Boston University as the Inaugural Theodore Moustakas Chair Professor 
 in Photonics and Optoelectronics in summer 2017. Cheng is authored in 300+
  peer-reviewed articles with an h-index of 94 (Google Scholar). Cheng and 
 his team has been constantly at the most forefront of the chemical imaging
  field in innovation\, discovery\, and clinical translation. Chemical micr
 oscopes based on his innovations\, including CARS\, hyperspectral SRS\, mi
 d-infrared photothermal microscopes\, are installed and used in many count
 ries worldwide. His research has been supported by over 40 million ($) fun
 ding from federal agencies including NIH\, NSF\, DoD\, DoE and private fou
 ndations including Chan-Zuckerburg Initiative and Keck Foundation. In 2014
  He co-founded Vibronix Inc which is devoted to vibration-based imaging te
 chnologies and medical device innovations. In 2019\, he co-founded Pulseth
 era aiming to kill superbugs by photolysis of intrinsic chromophores. In a
 ddition\, Cheng is the Scientific Advisor of Photothermal Spectroscopy Cor
 p in Santa Barbara and Axorus in Paris. Cheng is a Fellow of Optical Socie
 ty of America\, a Fellow of American Institute of Medicine and Biological 
 Engineering\, and associate editor of Science Advances. Cheng initiated th
 e inaugural Gordon Research Conference on Chemical Imaging\, held in Easto
 n\, MA in August 2023. Among his honors\, Cheng received the 2020 Pittsbur
 gh Spectroscopy Award from the Spectroscopy Society of Pittsburgh\, the 20
 19 Ellis R. Lippincott Award from Optica\, Society for Applied Spectroscop
 y\, Coblentz Society\, the 2016 Research Award from Purdue University Coll
 ege of Engineering\, and the 2015 Craver Award from Coblentz Society. He w
 as chosen as the Boston University Innovator of Year 2022.\n 
LOCATION:BM 5202 https://plan.epfl.ch/?room==BM%205202
STATUS:CONFIRMED
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