BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Memento EPFL// BEGIN:VEVENT SUMMARY:How a dynamic metabolism could control the eukaryotic cell cycle DTSTART:20231027T160000 DTEND:20231027T164500 DTSTAMP:20260407T172759Z UID:fadc3fd3da63a1223504a3823c3d018da0ef3bef0fe35b384aef05b7 CATEGORIES:Conferences - Seminars DESCRIPTION:Matthias Heinemann (born July 1\, 1972) is a professor of mol ecular systems biology at the University of Groningen. Heinemann leads an interdisciplinary lab of approximately 12 graduate students and post-doct oral scholars.[6] Until 2019\, he served as the chairman of the Groningen Biomolecular Sciences and Biotechnology Institute\,[7][8] was a board me mber of the Dutch Origins Center[9]and the coordinator of EU ITN project M etaRNA.[10] Heinemann is a member of the Faculty of 1000.[11]\nHeinemann received his degree (Dipl.-Ing.) in environmental engineering from the Un iversity of Stuttgart. In 2003\, he obtained a Ph.D. in biochemical engi neering (summa cum laude) from the RWTH Aachen University\, after which h e joined the Bioprocess lab of ETH Zurich as a postdoc. In 2006\, he joi ned the Institute of Molecular Systems Biology[12] of ETH Zurich as a g roup leader in the research unit of Uwe Sauer. In 2010\, he moved to the U niversity of Groningen as an associate professor\, where he got promoted t o full professor in 2013.\nThe eukaryotic cell division is thought to be c ontrolled by periodic activity of the cyclin dependent kinase (CDK) machin ery. However\, the fact that CDKs came late in the evolution of eukaryotes \, and the fact that oscillations in global transcription and the anaphase promoting complex activity were also found in during cell cycle arrest\, suggest that cell cycle regulators other than the cyclin/CDK machinery cou ld exist as well. We hypothesized that an autonomous metabolic oscillator could represent such global cell cycle regulator. Using microfluidics tech nology\, in combination with single-cell metabolite and cell cycle reporte rs\, we found that yeast metabolism is a CDK-independent oscillator\, whic h orbits across nutrients and at different metabolic modes\, in synchrony with the cell cycle\, but also in non-dividing cells. With environmental p erturbations and conditional protein depletion experiments\, we found that the metabolic oscillator and the cyclin/CDK machinery form a system of co upled oscillators\, where the metabolism gates the early and the late cell cycle. Most recently\, we have found that the metabolic oscillations emer ge from a temporal segregation in the biosynthetic processes. Overall\, th is work suggests that cell cycle control emerges as a higher order functio n from coupled and mutually entrained oscillators\, including a metabolic/ biosynthetic oscillator. Given the evolutionary conservation of metabolic pathways across life kingdoms\, such oscillator may constitute an ancestra l regulator of cell division. LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 STATUS:CONFIRMED END:VEVENT END:VCALENDAR