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SUMMARY:Asymmetry\, Phase Transitions\, and Temperature-Dependent Molecula
 r Transport in Cell Membranes
DTSTART:20231020T140000
DTEND:20231020T150000
DTSTAMP:20260414T103510Z
UID:b0a94f73902fc561962111c79a0c4d18d8dc9ec3fb21c7c528090ba9
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Hai-Lung Dai\, Institute for Membranes and Interfaces\, 
 Temple University\, Philadelphia\, PA (USA)\nBIOENGINEERING SEMINAR\n \nA
 bstract:\nSecond Harmonic Light Scattering\, a surface-sensitive phenomeno
 n\, can be used to observe molecular adsorption and transport at cell memb
 ranes with real-time and spatial resolutions. From transport rate measured
  for a hydrophobic ion (Malachite Green) as a function of temperature in t
 he range of 10-40ºC through 1) the cytoplasmic membrane (CM) of the Gram-
 negative bacterium E. coli and 2) the membrane of liposomes made of E. col
 i CM lipid extract\, we have observed dramatic decrease of molecular trans
 port rate from human body temperature to refrigerator temperature. The tem
 perature dependent transport rates display effects of two phase transition
 s from a gel to a mixed to a liquid-disordered phase. The adsorption equil
 ibrium constant measured as a function of temperature also displays charac
 teristics mimicking the two phase-transitions\, but the transition tempera
 tures for the two leaflets of the liposome membrane are determined to diff
 er. Based on experimentally measured adsorption equilibrium constants at t
 he pure gel vs the pure liquid-disordered phases\, ratios of gel vs liquid
 -disordered phases in the mixed phase of the two leaflets can be independe
 ntly determined. All experimental measurements on the adsorption equilibri
 um at the leaflet surface and the ratio of the gel vs liquid-disordered ph
 ases show that the structures of the two leaflets of this liposome are asy
 mmetric.\n\nBio:\nProf. Hai-Lung Dai\, is Laura H. Carnell Professor of Ch
 emistry and Director of the Institute for Membranes and Interfaces at Temp
 le University in Philadelphia\, PA (USA).\n\nResearch interests:\nNonlinea
 r optical and spectroscopic/microscopic studies of the structure and dynam
 ics of surfaces and interfaces\, colloidal particles\, aerosols\, nanopart
 icles\, micelles\, liposomes and biological cells\; structure and dynamics
  of new energy materials including RTIL\, DSSS\, and organic crystals and 
 thin films\; energy transfer and reactions of highly excited molecules.\n\
 nEducation:\n1981-1984    Postdoctoral researcher\, Massachusetts Inst
 itute of Technology\n1981             Ph.D. University of Cali
 fornia\, Berkeley\n1974             B.S. National Taiwan Unive
 rsity\n\nSelected Awards:\nEllis Lippincott Award in Spectroscopy\, Optica
 l Society of America\, Society of Applied Spectroscopy\, and Coblentz Soci
 ety. Langmuir Lecturer Award\, American Chemical Society Division of Collo
 id and Surface Chemistry. Coblentz Award in Molecular Spectroscopy. H.L. D
 ai Festschrift\, Journal of Physical Chemistry. American Chemical Society 
 Philadelphia Section Award. Fellow\, American Chemical Society. Fellow\, A
 merican Physical Society.  Guggenheim Fellow. Dreyfus Teacher-Scholar Awa
 rd. Sloan Fellow. Michael P. Malone International Leadership Award\, Assoc
 iation of Public and Land Grant Universities. Knight of the Order of the I
 talian Star\, Government of Italy. Distinguished Alumni Award\, National T
 aiwan University.
LOCATION:BM 5202 https://plan.epfl.ch/?room==BM%205202
STATUS:CONFIRMED
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