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SUMMARY:Epigenetic factor competition can reshape the EMT landscape in bre
 ast cancer cells
DTSTART:20231023T161500
DTEND:20231023T171500
DTSTAMP:20260502T210537Z
UID:4eee9cc87127a7535d3cacd4be8b9d66165f07f61e3212a741889754
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Herbert Levine\, Northeastern University\, Boston\nWe ar
 e nearing the tenth anniversary of the first papers applying methods of co
 mputational systems biology to the study of the epithelial-mesenchymal tra
 nsition (EMT) and its relevance to cancer metastasis. This undertaking has
  been a major success\, leading to a much-improved understanding of EMT it
 self and its connection to tumor initiation and drug resistance. But of co
 urse\, new questions have arisen. After surveying the state of the field\,
  this talk will focus on one of those new questions\, namely how EMT circu
 its may couple to epigenetic factors. Specifically\, we will argue that ep
 igenetics can play a critical in enabling EMT or its reverse (MET) and tha
 t constructing models of these effects must take into global competition f
 or epigenetic modifying enzymes.
LOCATION:CE 1 1 https://plan.epfl.ch/?room==CE%201%201
STATUS:CONFIRMED
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