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SUMMARY:Reconstituting Mouse Embryogenesis Ex Utero in Natural and Stem Ce
 ll Embryos
DTSTART:20231027T124000
DTEND:20231027T134000
DTSTAMP:20260604T000345Z
UID:db94360023f1a6325bf5a23f602626d7e54e689a5be6ad444193e7d4
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Alejandro Aguilera Castrejon\nAfter implantation\, mammalia
 n embryos initiate the process of gastrulation\, in which pluripotent epib
 last transits from a symmetrical ball of cells into an advanced embryo wit
 h a defined body plan. Yet\, the small size and intrauterine confinement o
 f the developing embryos limits the study of post-implantation embryogenes
 is\, due to the inability to observe and manipulate living embryos at thes
 e stages. We have devised efficient platforms for ex utero culture of earl
 y post-implantation mouse embryos\, enabling proper development of embryos
  between pre-gastrulation (embryonic day E5.5) until the hindlimb formatio
 n stage (E11). These culture systems allow the introduction of a variety o
 f embryonic perturbations and micro-manipulations\, which can be followed 
 ex utero in living embryos. Further\, by adapting the ex utero culture for
  growing stem cell-embryo models\, we established mouse stem cell-derived 
 embryos (sEmbryos) capable of completing gastrulation and early organogene
 sis when cultured ex utero. These stem-cell-derived embryos resemble E8.5 
 natural embryos and contain both embryonic and extraembryonic compartments
  originated from naïve pluripotent stem cells as the sole stem cell sourc
 e. The ability to continuously culture natural and stem-cell mouse embryos
  ex utero for long-term opens new possibilities for understanding mammalia
 n embryogenesis by allowing experimentation in living embryos during stage
 s that have remained hidden inside the maternal uterus\, and paves the way
  for implementing analogous culture methods in non-human primates and huma
 n embryos.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/63588282920
STATUS:CANCELLED
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