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PRODID:-//Memento EPFL//
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SUMMARY:Transposable Elements: from epigenomics to precision oncology
DTSTART:20231117T133000
DTEND:20231117T153000
DTSTAMP:20260407T195133Z
UID:bfbbdf71ebd87aa3c326f39673a05efb96d97a39702dc145eab10bb2
CATEGORIES:Conferences - Seminars
DESCRIPTION:Özgen Deniz\, Gael Cristofari\nJoin us for two back-to-back\,
  interactive seminars by prominent group leaders conducting cutting-edge r
 esearch on the role of transposable elements (TEs) in cancer. In the wake 
 of the Next Generation Sequencing revolution\, TEs are starting to reveal 
 their not-so-subtle effects on tumor biology: they drive oncogene expressi
 on\, disrupt tumor suppressors and potentiate immunotherapies through vira
 l mimicry and the generation of neoantigens.\n\nThe schedule has been set 
 so as to save time for discussions animated by members of the Trono Lab\, 
 to which all are invited to participate.\n\nProgram:\nÖzgen Deniz: Multi-
 faceted roles of retrotransposons in cancer genomes\nGael Cristofari: The 
 epigenetic and transcriptional interplay between L1 retrotransposons and t
 heir integration sites\n\nÖzgen Deniz has recently launched her group at 
 the Barts Cancer Institute in London. There\, she and her team aim to unde
 rstand the epigenetic regulation of TEs and how their dysregulation contri
 butes to the generation and development of blood cancers. In particular\, 
 they investigate the role of TEs as gene regulators and triggers of anti-t
 umor immunity in blood cancers\, with their eyes set on novel anti-cancer 
 therapies. During her postdoctoral stay in Miguel Branco’s group\, Özge
 n has notably co-pioneered a CRISPR-based biotechnology allowing the simul
 taneous epigenetic perturbation of thousands of phylogenetically related T
 E integrants\, which she then leveraged to show that TE-located epigenetic
  marks control growth in models of acute myeloid leukemia.\n\nGael Cristof
 ari is a renowned figure in the field and leads the Retrotransposons and G
 enome Plasticity group at the Institute for Research on Cancer and Aging i
 n Nice. There\, he and his team study L1HS\, the only TE subfamily still c
 apable of autonomous self-replication in the human genome. Despite contrib
 uting to human genetic variation - including pro-tumorigenic neo-insertion
 s - L1HS remain understudied\, as non-reference insertions and extreme lev
 els of sequence similarity confound standard NGS approaches. Gael and his 
 team have established a deep-sequencing method tailored for comprehensivel
 y mapping the position of L1 elements in individual human genomes\, as wel
 l as variations of this technique to assess the DNA methylation level of e
 ach L1 copy genome-wide. Gael is an alumnus of the Lingner Lab here at EPF
 L\, where he completed postdoctoral research on telomere extension which\,
  like retrotransposition\, relies on reverse transcription.\n\nChairs: Dan
 ica Milovanovic & Romain Forey | Trono Lab EPFL
LOCATION:BC 420 https://plan.epfl.ch/?room==BC%20420 https://epfl.zoom.us/
 j/69976213226?pwd=VUh3VjhrVExkcHlnMEVFR3hJbkd6UT09
STATUS:CONFIRMED
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